Anamorelin

Anamorelin works by stimulating the ghrelin receptor GHS-R1a.

1. Drug name and main ingredients

1. Generic name : AnamorelinHyd rochloride)

2. Trade name :ADLUMIZ Tablets

3 , Dosage form : Oral film-coated tablets

4. Main ingredients : Each tablet contains 50 mg of anamulin hydrochloride

2. Indications

1. Cancer cachexia : Used to treat cancer cachexia in patients with non-small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer. The following conditions must be met:

Weight loss ≥5% within 6 months and accompanied by loss of appetite;

2. At least two of the following are present at the same time:① Fatigue/burnout; ② Decreased body muscle strength; ③CRP>0.5mg/dL or hemoglobin <12g/dL or albumin <3.2g/dL.

3. Specifications and properties

1. Specifications : 50mg/tablet, light yellow film-coated tablet, long diameter approximately 14.1mm, short diameter approximately 6.6mm, thickness approximately 5.2mm, mass approximately 364mg.

2. Packaging : 100 pieces/bottle (10 pieces × 10 PTP board).

IV. Usage and dosage

1. Conventional dosage of : Adults take 100mg (2 tablets) once a day, orally on an empty stomach (fast within 1 hour after taking the medicine).

2. Treatment of missed doses : Skip the dose after more than 6 hours and take it as originally planned the next day; no need to take another dose after vomiting.

3. Efficacy evaluation : If there is no weight gain or appetite improvement within 3 weeks, the drug should be discontinued.

5. Medication precautions

1. Monitoring requirements :

Check electrocardiogram (PR/QRS/QT interval), liver function, blood sugar, and electrolytes regularly before and during treatment.

See a doctor if you develop heart palpitations, jaundice, or persistent nausea.

2. Dietary taboos :

Avoid grapefruit juice (inhibits CYP3A4 metabolism).

6. Medication for special groups

1. Pregnant women: : Disabled (animal experiments show embryotoxicity).

2. Lactation : Breastfeeding is prohibited during treatment and within 1 week after stopping the drug.

3. Liver damage :

Moderate (Child-PughB) dosage needs to be reduced to 50mg/day;

Severe (Child-PughC) is prohibited.

4. U200c for the elderly: No dose adjustment is required, but cardiac function needs to be closely monitored.

7. Adverse reactions

1. Common (≥5%) : Abnormal electrocardiogram (10.7%), hyperglycemia (4.3%), liver dysfunction (6.4%), nausea (35%), diarrhea (13%).

2. Severe reactions : Atrioventricular block, QT interval prolongation, acute liver injury.

8. Contraindications

1. People who are allergic to ingredients;

2. Patients with congestive heart failure, myocardial infarction or angina pectoris;

3. Severe conduction system disorders (such as complete atrioventricular block);

4. Combined use of strong CYP3A4 inhibitors (such as clarithromycin, itraconazole).

9. Drug interactions

1. CYP3A4 inhibitor : Strong inhibitors (such as ketoconazole) increase the plasma concentration by 3.2 times;

2. CYP3A4 inducer :Rifampicin reduces the plasma concentration by 68%;

3. Antiarrhythmic drug :Combined use may increase the risk of QT interval prolongation.

10. Storage method

Save at room temperature (20-25°C), away from light and moisture. The PTP package needs to be taken out before consumption.