Natacyn

[Drug name] Natamycin eye drops

[Common name] Natamycin eye drops

[Ingredients]

Natamycin

[Characteristics]

This product is a white to yellow suspension liquid

[Indications]

5% natamycin is suitable for fungal blepharitis, conjunctivitis and keratitis caused by microorganisms that are sensitive to this product, including Fusarium solani keratitis. As with other types of purulent keratitis, the timing of initiation and continuation of treatment for fungal keratitis should be determined based on clinical diagnosis, laboratory tests such as smears and corneal scraping cultures, and response to medications. If possible, the activity of natamycin against the fungi of interest should be determined in vitro. The effectiveness of natamycin alone in the treatment of fungal endophthalmitis has not been established.

[Specifications]

15ml

[Usage and Dosage]

Please shake well before use. The optimal starting dose of 5% natamycin for the treatment of fungal keratitis is 1 drop every 1-2 hours, instilled into the conjunctival sac. After 3-4 days, change to 1 drop each time, 6-8 times a day. Treatment generally lasts for 14-21 days or until active fungal keratitis subsides. In most cases, gradual reduction of the drug dosage every 4-7 days is necessary to ensure elimination of pathogen replication. The initial dose for the treatment of fungal blepharitis and conjunctivitis can be smaller, 1 drop each time, 4-6 times a day.

[Adverse reactions]

It has been reported that there was a case of bulbar conjunctival edema and congestion, but it was actually caused by allergies.

[Contraindications]

Natamycin is contraindicated in patients with a history of allergy to any component of this product.

[Notes]

1. General: only for eye drops, not for injection. If the keratitis does not improve after using this product for 7-10 days, it means that the microorganism causing the infection is not sensitive to natamycin. The decision to continue treatment should be based on clinical re-evaluation and other laboratory test results. Apply this product regularly to epithelial ulcers or drop it on the fornix. Due to the limited number of cases using natamycin, there may be some adverse reactions that we have not yet observed. Therefore, it is recommended that patients using this product be checked at least twice a week. If suspected drug toxicity occurs, use should be stopped immediately.

2. Instructions to patients: Do not touch the mouth of the medicine bottle to prevent contamination of the medicine liquid.

[Drug for pregnant and lactating women]

1. Pregnant women: For pregnant women, natamycin is a Class C drug. Animal fertility studies have not been conducted with natamycin, and it is not known whether natamycin may harm the fetus or affect fertility when used in pregnant women. Only use this product to pregnant women when necessary.

2. Breastfeeding women: It is unclear whether this product will be secreted through human milk. However, since many drugs can be excreted through human milk, breastfeeding women should use them with caution.

【Children's Medication】

The safety and efficacy in children are not yet completely clear.

[Drug use in the elderly]

This experiment has not been conducted and there are no reliable references.

[Pharmacology and Toxicology]

Drug effects:

Natamycin is a tetraene-polyene antibiotic extracted from Streptomyces NATALENSIS. It has in vitro activity against a variety of yeasts and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Its mechanism of action is through the combination of drug molecules with sterol molecules in the fungal cell membrane to form a polysterol complex, which changes the permeability of the cell membrane and exhausts the basic cellular components in the fungal cell. Although this antifungal effect is dose-related, natamycin remains a potent fungicide. Natamycin has no effect against Gram-positive and Gram-negative bacteria in vitro. Topically applied natamycin can achieve effective concentrations within the corneal stromal layer but not in the intraocular fluid. 5% natamycin administered locally cannot be absorbed systemically. As with other polyolefin antibiotics, very minimal amounts of this drug are absorbed through the gastrointestinal tract. The results of a study using natamycin in rabbits showed that the drug could not be detected in the aqueous humor or serum, but the sensitivity of the measurement did not exceed 2mg/ml.

Toxicological studies:

Carcinogenesis, mutagenesis and fertility impairment: There is no long-term evaluation data on the carcinogenesis, mutagenesis and fertility impairment of natamycin in animals.

[Storage]

Can be stored in the refrigerator at 2-8℃. Or store at room temperature 8-24°C. Not suitable for freezing. Avoid light or excessive heat.