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Common name: Trientine
Trade name: Syprine
Full names: Trientine capsules, Trientine, Syprine
Indications:
Mainly used for patients with hepatolenticular degeneration (Wilson's disease) who are intolerant to penicillamine or who have relapsed after taking penicillamine.
Usage and dosage:
Oral administration.
Adult dosage: 0.75~1.25g per day, divided into 2~4 times, taken on an empty stomach, the maximum dose is 2g per day.
Pediatric dose: 0.5~0.75g per day, the maximum dose for children under 12 years old is 1.5g per day.
Adverse reactions:
Can cause iron deficiency anemia, occasionally heartburn, abdominal pain, acute gastritis, loss of appetite, rash, myalgia, etc.
Contraindications:
People allergic to this product should not use it, and nursing mothers and pregnant women should use it with caution or do not use it.
Notes:
1. The safety of children under 6 years old has not been established.
2. When supplementing iron, the two doses must be separated by 2 hours.
3. Wait at least 1 hour after taking this product before taking other food, medicine or dairy products.
4. Serum copper concentration should be monitored.
5. Do not use it interchangeably with penicillamine.
Storage:
Sealed and stored
Mechanism of action:
Trientine is a copper complexing agent used to treat Wilson's disease. Its effect is similar to that of penicillamine and it can promote the excretion of copper through the kidneys. Although it is not as effective as penicillamine, it can be used by patients who cannot tolerate penicillamine.
Safety and efficacy:
Both AASLD and EASL pointed out that the initial treatment for patients with symptomatic Wilson disease is to give chelating agents such as penicillamine or trientine. In comparison, trientine is better tolerated. Vieira et al noted that due to adverse effects of penicillamine as a first-line chelating agent, half of the patients were switched to trientine. Ala et al. proposed that single use of trientine once/day can significantly improve treatment compliance.