Canaglu

Canagliflozin hydrochloride is an oral hypoglycemic drug that is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It inhibits the reabsorption of glucose by the kidney and promotes urinary glucose excretion to lower blood sugar.

1. Drug name

1. Common name :Canagliflozin hydrochloride (canagliflozin water purifier)

2. Trade name u2 00c:Canaglu(カナグル町)

3. English name :CanagliflozinHydrate

2. Suitable Symptoms

1. Type 2 diabetes (needs to be combined with diet and exercise therapy)

2. Type 2 diabetes combined with chronic kidney disease (eGFR≥30mL/min /1.73m², excluding dialysis patients)

3. Specifications and properties

1. Specifications :

100mg/tablet

2. Properties of :

(1), Ordinary tablet : light yellow film-coated tablet, diameter 7.6mm, thickness 3.4mm

(2), Orally disintegrating tablet (OD) : light yellow-brown plain tablet, 9.5mm in diameter, 4.4mm thick

IV. Main ingredient

1. Active ingredient :card Gliflozin water and substance (102mg/tablet, equivalent to canagliflozin 100mg)

2. Excipients :D-mannitol, hydroxypropylcellulose, croscarmellose sodium, etc. (ordinary There are slight differences in excipients between tablets and OD tablets)

5. Usage and dosage

1. Conventional dosage of :100mg once a day, taken orally before or after breakfast.

2. Dose adjustment :

(1) Renal insufficiency :

eGFR30-45mL/min/1.73m²: use with caution and monitor renal function;

eGFR<30mL/min/1.73m²: disabled (ineffective blood sugar control or insufficient renal protection).

(2) Liver dysfunction : no adjustment is needed for mild to moderate, and no data for severe (Child-Pugh C grade).

6. Medication precautions

1. Pre-meal/post-meal : It can be taken before or after a meal. Food may delay absorption but does not affect the total exposure.

2. If you miss a dose of : Take it as soon as possible. If it is close to the next dose time, skip it. Do not double the dose.

3. Vomiting : If you vomit immediately after taking the medicine, it is recommended to take a supplement; if it has been absorbed (>1 hour), there is no need to take a supplement.

4. OD tablet : It can be taken lingually (no water required) or taken with water, but bedridden patients need to take it with water to prevent aspiration.

7. Medication for special groups

1. Pregnant women: : Contraindicated (animal experiments show the risk of fetal kidney damage).

2. U200c during lactation: It is recommended to discontinue the drug (drugs are detected in breast milk).

3. Children : No security data, disabled.

4. Elderly people : Need to be cautious as dehydration or hypoglycemia may easily occur.

8. Adverse reactions

1. Common (≥1%):

Urinary tract infection, genital fungal infection, hypoglycemia (when combined with insulin/sulfonylurea), polyuria.

2. Severe :

Ketoacidosis (may not have typical symptoms of hyperglycemia);

Dehydration-related thrombosis/acute kidney injury;

Necrotizing fasciitis (perineal), pyelonephritis.

9. Contraindications

Those who are allergic to ingredients;

Type 1 diabetes or diabetic ketoacidosis;

Those who require insulin treatment during severe infection/trauma/surgery;

Dialysis or eGFR<30mL/min/1.73m² (except for renal protection indications).

10. Drug interactions

1. Use with caution:

Diuretics (aggravate dehydration);

Digoxin (plasma concentration ↑20%);

Rifampicin (canagliflozin exposure ↓51%).

2. Increased risk of hypoglycemia :

Insulin, sulfonylureas, fast-acting secretagogues.

11. Storage method

1. Conditions : Store at room temperature (avoid high temperature and humidity);

2. Validity period : 3 years;

3. PTP packaging : Need to take out the tablets to prevent accidental swallowing of aluminum foil.

12. Manufacturer

Manufacturer : Mitsubishi Tanabe Pharma, Japan;