Rilutor

Instructions for Riluzole Tablets (rilutek)
Common name: Riluzole Tablets
Trade Name: Rilutek
All names: Riluzole Tablets, Rilutek, rilutek, riluzole, Rilutor

Indications:
For the treatment of patients with amyotrophic lateral sclerosis, it can prolong survival and/or delay the time of tracheotomy.

Usage and dosage:
Oral administration, 50 mg (1 tablet) once, 2 times a day. Increasing the daily dosage will not increase the efficacy of the drug, but it will increase the adverse reactions.
If you miss one dose, take the next 1 tablet as originally planned.
The medication should be taken 1 hour before or 2 hours after a meal to reduce the impact of food on the bioavailability of riluzole.

Adverse reactions:
Common adverse reactions of this product are fatigue, stomach discomfort, and increased plasma aminotransferase levels. Other adverse reactions are less common.
Neutropenia is occasionally seen.
This product may cause other adverse reactions not listed here. If you have any changes in your health while taking this product, please inform your physician or pharmacist.

Contraindications:
Those allergic to this product and its main ingredients. Those with abnormal liver function or abnormally elevated transaminase levels. For use in pregnant and lactating patients.

Precautions:
Patients with liver disease should use with caution and check liver function regularly. Please inform your doctor if you have liver disease as this product may not be suitable for you. Excessive drinking should be avoided while taking this medicine. A decrease in the count of white blood cells (which have an important role in fighting infections) may occur. If you have any signs of fever (increased body temperature), contact your doctor immediately. Inform your physician if you have any kidney disease. If you feel dizzy or dizzy after taking this product, you should not drive or operate machinery.

Storage:
Save at room temperature (10-30℃).

Mechanism of action:
In the animal glutamate injury model, riluzole tablets had a significant protective effect on fetal rat motor neurons in a dose-related manner.
Riluzole tablets are synthesized by Rhone Poulenc Rorer Company, and their chemical structure is 2-amino-6-trifluoromethylbenthiazole. The drug freely crosses the blood-brain barrier. In rodent studies, the drug has an anticonvulsant effect. This property is similar to that of a dicarboxylic amino acid antagonist. It can resist the increase in guanosine monophosphate in the cerebral cortex and the release of acetylcholine in the olfactory tubercle and striatum induced by excitatory amino acids. Therefore, it is speculated that the drug can antagonize the transmission of excitatory amino acids such as glutamate; in acute In the model of acute cerebral ischemia, Riluzole Tablets can reduce memory function damage and degeneration of hippocampal pyramidal neurons, which further suggests the relationship between Riluzole Tablets and glutamate. Moreover, Estevezr reported that in the animal glutamate injury model, Riluzole Tablets had a significant protective effect on fetal rat motor neurons, which was dose-related.

Efficacy and safety:
Riluzole tablets are suitable for prolonging the life of patients with amyotrophic lateral sclerosis (ALS) or prolonging the time until they require mechanical ventilation support.
Clinical trials have proven that riluzole tablets can prolong the survival of ALS patients. Survival was defined as surviving patients who did not require intubation for mechanical ventilation and did not undergo tracheostomy.
There is no evidence that riluzole tablets have a therapeutic effect on motor function, lung function, fasciculations, muscle strength and motor symptoms. Riluzole tablets have not shown efficacy in patients with advanced ALS.
The safety and effectiveness of Riluzole Tablets have only been studied in ALS. Therefore, riluzole tablets should not be used for any other type of motor neuron disease.