依普利酮推荐用量多少？

Binds to mineralocorticoid receptors, thereby blocking the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone synthesis occurs primarily in the adrenal gland and is regulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in epithelial tissues (such as the kidneys) and non-epithelial tissues (such as the heart, blood vessels, and brain) and increases blood pressure by inducing sodium reabsorption and possibly other mechanisms. 

What is the recommended dosage of eplerenone? 

Common doses for adults with congestive heart failure: Initial dose: 25 mg orally, once daily; gradually increase to target dose within 4 weeks as tolerated by the patient. Target dose: 50 mg orally once daily. Common dosages for adults with hypertension: Eplerenone can be used alone or in combination with other antihypertensive drugs. Initial dose: 50 mg orally once daily. Maintenance dose: 50 mg orally, 1-2 times daily. Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily. Use eplerenone with caution in patients with moderate to severe hepatic impairment. As kidney function decreases, the risk of hyperkalemia increases. Use with caution in patients with mild renal impairment; it may be disabled depending on the indications and degree of damage.

Things to note: 1. Liver damage: Use with caution in patients with moderate to severe liver damage; 2. Kidney damage: As kidney function declines, the risk of hyperkalemia increases. Use with caution in patients with mild renal impairment; may be disabled based on indications and degree of impairment; 3. Drug-drug interactions: Significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapies; 4. Potassium supplements: Avoid potassium supplements, potassium-containing salt substitutes, potassium-rich diets, or other drugs that may cause hyperkalemia (such as other potassium-sparing diuretics, nonsteroidal anti-inflammatory drugs). Concomitant use of potassium supplements or potassium-sparing diuretics is contraindicated in the treatment of hypertension.