依普利酮怎么用呢？

Hypertension refers to a clinical syndrome characterized by an increase in systemic arterial blood pressure (systolic blood pressure and/or diastolic blood pressure) (systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg), which may be accompanied by functional or organic damage to the heart, brain, kidneys and other organs. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. (eplerenone) is the first selective aldosterone receptor antagonist. It has been used to treat hypertension and left ventricular dysfunction after acute myocardial infarction. It can effectively lower blood pressure, improve cardiac function, and reduce myocardial damage.

In patients with low-renin hypertension, the antihypertensive effect of eplerenone is better than that of losartan. For patients with hypertension who are poorly controlled by ARB alone, adding eplerenone (50~100 mg·d) for 8 weeks can further enhance the effect of reducing systolic blood pressure (SBP) and diastolic blood pressure (DBP). For elderly patients with hypertension who are poorly controlled by ACEI or ARB, the addition of low-dose (25-50 mg/d, average 37.5 mg) eplerenone can effectively reduce the average 24-hour systolic blood pressure (SBP) and diastolic blood pressure (DBP).

Common doses for adults with congestive heart failure: Initial dose: 25 mg orally, once daily; gradually increase to target dose within 4 weeks as tolerated by the patient. Target dose: 50 mg orally, once daily.

Common dosages for adults with hypertension: Eplerenone can be used alone or in combination with other antihypertensive drugs.

Initial dose: 50 mg PO once daily

Maintenance dose: 50 mg orally, 1-2 times daily

Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.

Use with caution in patients with moderate to severe liver damage. As kidney function decreases, the risk of hyperkalemia increases. Use with caution in patients with mild renal impairment; it may be disabled depending on the indications and degree of damage.