地舒单抗是哪产的呢？

It is a humanized IgG2 monoclonal antibody produced in mammalian (Chinese hamster ovary) cells through genetic engineering. Its molecular formula is C6404 H9908 N1724 O2004 S50, and its relative molecular mass is approximately 147,000.

In June 2010, the US FDA approved denosumab (trade name: Prolia) for the treatment of osteoporosis in postmenopausal women, and was later approved for the treatment of male osteoporosis, bone loss caused by androgen deprivation therapy for prostate cancer, and bone loss caused by aromatase inhibitor therapy for breast cancer.

Desosumab is administered by injection, 120 mg subcutaneously in the upper arm, upper thigh, or abdomen, once every 4 weeks, with calcium and vitamin D when needed to treat or prevent hypocalcemia.

The original manufacturer of denosumab is Amgen of the United States. Amgen is principally engaged in the discovery, development, production and sales of innovative drugs for human use, and is committed to exploring the potential of biotechnology for the treatment of patients with serious diseases. By leveraging cutting-edge human genetics and other tools, Amgen seeks to unravel the complexity of disease and lay the foundation for understanding human biology.

On May 27, 2019, Amgen China announced the launch of denosumab in my country. This approval makes denosumab the first and currently the only drug for the treatment of giant cell tumor of bone, bringing patients an innovative treatment option to control disease progression and improve quality of life.

However, due to the short time that denosumab has been on the market in my country, denosumab is not available in any hospital in the country. Moreover, the original drug on the market in my country is relatively expensive. Without medical insurance reimbursement, it is a huge expense for patients and difficult to afford.

Medical Travel has learned that the product produced by the American company Amgen is on the market in Turkey and is relatively cheap. The specification is 125mg/1ml tube/box, and the equivalent price in RMB is about 3,000$.