What are the uses, contraindications, precautions and effects of progesterone soft capsules?

Progesterone soft capsules are indicated for the treatment of irregular menstrual cycles and as a supplement to estrogen replacement therapy in postmenopausal women with an intact uterus. This drug is contraindicated for patients who are allergic to the active substances of this drug, soybeans and other ingredients, and patients with liver tumors. Note that progesterone soft capsules cannot be used as contraceptives. The clinical therapeutic effect of progesterone soft capsules varies from person to person, but it usually has a certain effect.

Uses of progesterone soft capsules

Progesterone soft capsules are suitable for adults and can be used to treat irregular menstruation and menstrual cycle disorders caused by luteal insufficiency. It can also be used as hormone replacement therapy to provide additional treatment with estrogen in postmenopausal women with intact uteruses. In addition, progesterone softgels have been shown to be an effective oral alternative for preventing normal ovulation and premature luteinizing hormone surge in patients with polycystic ovary syndrome (PCOS).

Contraindications of progesterone soft capsules

1. Patients who are allergic to active substances, soybeans, peanuts or any other ingredients in refined sunflower oil, soy lecithin, gelatin glycerol dioxide. Progesterone softgels contain soy lecithin, which may cause allergic reactions (hives and anaphylactic shock). Progesterone softgels should not be used by patients with soy or peanut allergies.

2. Patients with persistent bleeding from the genital area, unexplained vaginal bleeding or missed miscarriage are prohibited from taking this product.

3. Severe liver dysfunction. Patients with severe liver disease or liver dysfunction are prohibited from taking this product.

4. This drug is contraindicated in patients with liver tumors, suspected or known malignant tumors of the breast or reproductive organs, previous or current thromboembolic diseases, cerebral hemorrhage, and porphyria.

Dosage forms and specifications

Progesterone Softgels 100 mg: Round, yellowish softgels containing white oily pension.

Progesterone Softgels 200 mg: Round, yellowish softgels containing white oily pension.

Precautions for progesterone soft capsules

1. Drug absorption: Micronized progesterone can be absorbed in the digestive tract. Progesterone concentrations in the blood increase within the first hour after ingestion and reach maximum plasma concentrations 1 to 3 hours after ingestion. Because the hormone accumulates in tissues, it should be taken in two doses daily, 12 hours apart. This way the hormones are available within 24 hours.

2. Adjust the drug dose: If drowsiness or temporary dizziness occurs, the dose should be reduced or progesterone should be taken before going to bed at night and divided into 10 cycles. If the cycle is shortened or spotting occurs, treatment should be started later in the cycle (such as day 19 instead of day 17). Estradiol concentrations in perimenopausal and menopausal hormone replacement therapy should be checked for adequacy.

3. Breastfeeding: There is insufficient information on the excretion of progesterone or its metabolites in breast milk. Whether progesterone is secreted into breast milk has not been adequately studied, but since most drugs are metabolized into breast milk, breastfeeding is not recommended and Euthyrox should not be used while breastfeeding.

4. Bleeding: Women with intact endometrium may experience periodic abortion-like bleeding in the early stages of treatment. During long-term treatment, as endometrial atrophy intensifies, this bleeding may decrease or stop completely. If these discontinuous bleedings do not occur, appropriate measures must be taken to rule out the possibility of endometrial hyperplasia.

During the first few months of treatment, breakthrough bleeding and spotting may occur. If such bleeding occurs late in treatment, or continues after the end of treatment, the cause must be identified and an endometrial biopsy may be necessary to rule out malignant disease of the endometrium.

5. Examination: Before starting or resuming hormone replacement therapy, the patient's personal and family medical history should be understood. Physical examination (including abdomen and breast) should be based on this history as well as contraindications and warnings. During treatment, regular check-ups are recommended, with the frequency and type of check-ups depending on the woman's individual risk profile. Women should be informed about changes in their breasts that they should report to their doctors.

Examination, including imaging procedures such as mammography, should be performed based on current screening practices and each woman's clinical needs.

6. Discontinue the drug: Since metabolic risks and thromboembolism risks cannot be completely ruled out, you should stop taking the drug if the following conditions occur.

Eye disorders such as impaired vision, diplopia and retinal vasculopathy, venous thromboembolism or thrombotic events regardless of the occurrence

, severe headache.

Progesterone soft capsules

Progesterone soft capsules contain micronized progesterone, which can significantly increase plasma progesterone concentration after oral administration. Therefore, it can

Supplement progesterone deficiency. Its active ingredient, progesterone, is chemically identical to the progesterone produced by the corpus luteum during the female ovarian cycle. It has multiple biological effects, particularly on target tissues previously affected by estrogen. Progesterone converts the proliferating endometrium into secretory endometrium. In postmenopausal women, the estrogen gene promotes the growth of the lining of the uterus. Using estrogen alone increases the risk of endometrial hyperplasia or endometrial cancer. In unhysterectomized women, additional progesterone therapy significantly reduces the risk of estrogen-induced endometrial hyperplasia.

In addition, for problems such as dysfunction caused by progesterone deficiency, menstrual irregularities caused by abnormal ovulatory function, dysmenorrhea, and premenstrual syndrome, progesterone soft capsules can effectively treat these symptoms by supplementing natural progesterone and increasing women's own progesterone levels. Using progesterone soft capsules according to the course of treatment can often significantly improve symptoms such as menstrual disorders, shortened menstrual cycles, irregular bleeding before menstruation, infertility, and threatened abortion in early pregnancy.

Drug preservation

The storage temperature of progesterone soft capsules should not exceed 30°C. Medications should not be stored in the refrigerator, but should be kept in the original packaging to protect them from moisture.

It should be noted that some people may experience uncomfortable symptoms such as dizziness and breast tenderness after using progesterone soft capsules. These symptoms usually disappear naturally after stopping the medication. Therefore, when using progesterone soft capsules, you need to do it under the guidance of a doctor and pay attention to the changes in your body.

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