A brief introduction to the adverse reactions, treatment and medication reference of the lung cancer drug Mobotinib

Introduction: Mobotinib is an effective treatment for patients with non-small cell lung cancer with EGFR exon 20 insertion mutations. By inhibiting the abnormal EGFR signaling pathway, it can block the growth and reproduction of tumor cells, providing new treatment options for patients. This article mainly talks about the adverse reactions and treatment of Mobotinib, medication reference, precautions, etc.

Adverse Reactions

The most common adverse reactions of mobotinib (>20%): diarrhea, rash, nausea, stomatitis, vomiting, decreased appetite, paronychia, fatigue, dry skin and musculoskeletal pain.

Management method: For mild diarrhea, it can be relieved by adjusting the diet, such as consuming low-fiber, easy-to-digest foods. If diarrhea is severe, you may need to temporarily stop taking the medication and ask your doctor if you need an antidiarrheal medication, such as loperamide. Antiemetic drugs, such as ondansetron, can be used to relieve nausea and vomiting symptoms. Patients are advised to avoid strong irritating smells or foods before and after taking the medication to reduce nausea.

Depending on the severity of the rash, topical or systemic anti-allergic or anti-inflammatory medications may be needed. If the rash is severe or persists, you should ask your doctor whether the dosage of the medication needs to be adjusted or discontinued. Maintain oral hygiene, brush teeth and rinse mouth regularly. If stomatitis symptoms are severe, topical anti-inflammatory medications or oral antibiotics may be needed. For other adverse reactions, such as fatigue, loss of appetite, paronychia, etc., a treatment plan needs to be formulated based on the severity of the symptoms and the specific situation of the patient. If serious adverse reactions occur or symptoms persist, you should consult a doctor promptly and follow the doctor's recommendations for treatment.

Medication Reference

Mobotinib for adults: Take orally once daily, the dose is 160 mg. Swallow capsules whole and do not open, chew or dissolve capsule contents. Take it at the same time every day, with or without food. If a dose is missed for more than 6 hours, the missed dose should not be replenished but should be continued at the scheduled time the next day. If you vomit after taking the medicine, do not take another dose. Instead, take the prescribed dose at a planned time the next day. For children, the elderly, and patients with renal or hepatic insufficiency, please refer to the relevant content in the instructions or consult a doctor.

Notes

1. Before starting treatment, assess the baseline QTc interval and electrolytes and correct any abnormalities. QTc and electrolytes should be monitored regularly during treatment. Frequent monitoring should be increased in patients with risk factors for QTc prolongation (such as congenital long QT syndrome, cardiac disease, or electrolyte abnormalities).

2. Monitor patients for new or worsening pulmonary symptoms of ILD/pneumonitis. Mobotinib should be discontinued immediately in patients with suspected ILD/pneumonitis and, if confirmed, permanently.

3. During medication, attention should be paid to monitoring cardiac function, including assessment of left ventricular ejection fraction at baseline and during treatment. Mobotinib may cause cardiotoxicity, including reduced ejection fraction, cardiomyopathy, and congestive heart failure.

4. Diarrhea may occur within 24 hours after taking , which may lead to dehydration or electrolyte imbalance. Start using antidiarrheal medications and increase fluid and electrolyte intake at the first onset of diarrhea or increased frequency of bowel movements.

Mobotinib has shown good efficacy in the treatment of non-small cell lung cancer and other diseases, but both patients and doctors should fully understand and comply with its medication precautions to ensure the safety and effectiveness of the medication. If you have any questions or discomfort, you should consult your doctor promptly.