Rivaroxaban列入医保了吗？

Rivaroxaban is used to prevent the formation of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients following hip and knee replacement surgery. It can also be used to prevent stroke and non-central nervous system embolism in patients with non-valvular atrial fibrillation, and reduce the risk of recurrence of coronary syndrome.

Rivaroxaban highly selectively and competitively inhibits free and bound factor Xa and prothrombin activity, prolonging the activated partial thromboplastin time (PT) and prothrombin time (aPTT) in a dose-dependent manner.

The essential difference between Rivaroxaban and fondaparinux sodium/heparin is that it does not require the participation of antithrombin III and can directly antagonize free and bound factor Xa. Heparin requires antithrombin III to work and is ineffective against factor Xa in the prothrombin complex.

The original research of Rivaroxaban is jointly developed by Bayer/Johnson & Johnson. Johnson & Johnson is responsible for the U.S. market, and Bayer is responsible for other global markets outside the United States. Rivaroxaban was first approved for marketing by the European Union in September 2008, and soon replaced warfarin in the European market.

In March 2009, Rivaroxaban was approved for marketing in China. So, is Rivaroxaban included in medical insurance?

In 2009, Rivaroxaban entered the national medical insurance directory and was limited to patients after lower limb joint replacement. In 2017, the national medical insurance catalog was adjusted, and Rivaroxaban expanded the scope of medical insurance reimbursement, limiting its use to patients with non-valvular atrial fibrillation who are poorly controlled by warfarin therapy or who are at high risk of bleeding, as well as patients after lower limb joint replacement. The departments eligible for clinical medical insurance reimbursement have been expanded from surgery to cardiovascular medicine.

In addition, there are some adverse reactions to taking Rivaroxaban, some of which may cause bleeding reactions, or other symptoms, such as allergies, which are of course relatively rare.