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Trametinib (Mekinist) instructions

Common name: Trametinib

Trade name: Mekinist

Full names: Trametinib, Mekinist, trametinib

[Trametinib indications]

As a single agent or in combination with dabrafenib for the treatment of unresectable or metastatic patients with BRAF Treatment of melanoma patients with V600E or V600K gene mutations.

Limitations of use: Trametinib as a single agent is not indicated for the treatment of patients receiving prior BRAF-inhibitor therapy.

[Trametinib dosage and administration]

(1) Confirm the presence of BRAF V600E and V600K mutations in tumor samples before starting treatment with trametinib.

(2) The recommended dosage regimen of trametinib is 2 mg orally once a day as a single agent and in combination with dabrafenib 150 mg orally twice a day. Take dabrafenib at least 1 hour before and 2 hours after a meal.

[Trametinib specifications]

0.5mg and 2mg.

[Adverse reactions of Trametinib]

(1) Common adverse reactions (≥20%) of Trametinib as a single agent include rash, diarrhea, and lymphedema.

( 2) The most common adverse reactions (≥20%) when trametinib is combined with dabrafenib include fever, chills, fatigue, rash, nausea, vomiting, diarrhea, abdominal pain, peripheral edema, cough, headache, arthralgia, night sweats, decreased appetite, constipation, and myalgia.

[Trametinib drug interactions]

(1) When trametinib is used in combination with dabrafenib, avoid coadministration of strong inhibitors of CYP3A4 and CYP2C8.

(2) When trametinib is used in combination with dabrafenib, avoid coadministration of strong inducers of CYP3A4 and CYP2C8.

(3) When trametinib is used in combination with dabrafenib, the concurrent use of drugs that are sensitive substrates of CYP3A4, CYP2C8, CYP2C9, CYP2C19, and CYP2B6 results in the loss of efficacy of these drugs.

[Use of trametinib in special populations]

(1) Breastfeeding mothers: Discontinue the drug and breastfeeding.

(2) Women and men of reproductive potential: Discuss pregnancy planning and prevention with female patients. May damage fertility.

[Storage of Trametinib]

The temperature requirement is 2°-8°, and it should be stored in the refrigerator and protected from light. Do not freeze.