有史以来最强DHT阻断剂：度他雄胺的功效及副作用

Studies have found that DHT is involved in mediating the expression of VEGF in prostate tissue. The reduction of DHT levels can inhibit the formation of new microvessels in prostatic hyperplasia (BPH), thereby reducing the microvessel density (MVD) in BPH tissue, thereby providing a theoretical basis for the use of 5α-reductase inhibitors to reduce the bleeding volume of TURP surgery. Animal experiments have confirmed that blocking androgens can effectively reduce the expression of VEGF and reduce blood flow in prostate tissue. DHT blockers can dually block type Ⅰ and type Ⅱ 5α-reductase. Theoretically, they have a faster onset time and more significant effect than finasteride. They are more advantageous in reducing bleeding during TURP surgery. Therefore, dutasteride deserves the title of the most powerful DHT blocker in history. The following is an introduction to the effects and side effects of Dutasteride.

Dutasteride is a second-generation agent. Compared with traditional fitasteride, it has a more obvious inhibitory effect on patients' serum DHT. It has a significant effect in reducing prostate volume, improving maximum urine flow, reducing IPSS and QOL scores, and reducing PSA levels. Studies have shown that under the combined treatment of dutasteride and tamsulosin, the volume of patients with prostatic hyperplasia is more significantly reduced, the obstruction of the patient's bladder outflow tract is significantly relieved, the control effect of detrusor instability is better, and the treatment effect is more stable.

Caused by: reduced sexual desire, reduced semen quantity, impotence, difficulty in ejaculation, enlargement and swelling of male breasts, etc. When patients use dutasteride, they must strictly follow the doctor's instructions and take the medication correctly, so that they can maximize the effect of dutasteride. During the medication period, patients must not increase or decrease the dose of the drug by themselves. Dutasteride will not improve the therapeutic effect just because the dose of the drug is increased, so do not use the drug blindly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.