一文带你了解度他雄胺这个药物

The stimulation of androgens is an important factor leading to the occurrence and development of prostatic hyperplasia (BPH). The androgens in the serum are mainly testosterone secreted by the testicles. Testosterone enters the prostate tissue and is combined with 5α-reductase to be converted into the more active dihydrotestosterone (DHT) before it can exert its biological effects and promote the development of prostatic hyperplasia (BPH). BPH; 5α-reductase inhibitors such as finasteride and (Dutasteride) are currently the first-line drugs for the treatment of BPH. Their main pharmacological mechanism is to inhibit the conversion of testosterone into DHT in the body. So today, the editor will use an article to introduce you to the drug dutasteride.

In recent years, many scholars at home and abroad have discovered that the 5α reductase inhibitor (Dutasteride) is more effective in inhibiting the progression of BPH among similar drugs, and can also improve the lower urinary tract symptoms caused by BPH. Many scholars have confirmed that Dutasteride can effectively reduce the incidence of hematuria in BPH patients.

Dutasteride is the first drug to inhibit both type I and type II 5α reductase. It can effectively combine with 5α reduced coenzyme to generate tri-$ compounds. This substance plays a blocking role in the gradual conversion of testosterone to dihydrotestosterone. During prostatic hyperplasia, α sympathetic nerve receptors in prostate tissue The body concentration is higher than that of normal prostate tissue. Dutasteride can significantly reduce the content of dihydrotestosterone and reduce the contraction of prostate glands and capsules. It can significantly reduce the size of the patient's prostate, significantly reduce urinary resistance, increase urinary flow rate, and improve obstruction symptoms. Therefore, it can significantly alleviate clinical symptoms such as dysuria in patients.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.