保法止非那雄胺片的功效和作用

Propecia Finasteride is a 4-azasteroid compound. It is a specific inhibitor of type II 5a-reductase, an intracellular enzyme that metabolizes testosterone into dihydrotestosterone. It can very effectively reduce dihydrotestosterone in the blood and prostate. That is, by inhibiting the conversion of testosterone into dihydrotestosterone (DHT), it reduces the size of the prostate and improves symptoms, increases urine flow rate, and prevents benign prostatic hyperplasia (BPH). Today let’s learn more about the efficacy and functions of Propecia Finasteride Tablets.

In the Propecia Finasteride Long-Term Efficacy and Safety Study (PLESS), 3016 patients with moderate to severe symptoms of BPH who took the drug for 4 years were evaluated for BPH-related urinary tract management (surgical intervention), such as transurethral resection of the prostate and other prostatectomy procedures, or acute urinary retention requiring insertion of a urinary catheter.

In this double-blind, randomized, placebo-controlled, multicenter study, treatment with Propecia finasteride reduced the overall risk of urinary tract disposition by 51% and was associated with significant and sustained prostate volume reduction, as well as sustained increases in maximum urinary flow rate and symptomatic improvement.

Finasteride is a synthetic drug mainly used as an androgen antagonist. This means that its mechanism is to inhibit the activity of androgen or steroid hormones. Specifically, Propecia finasteride inhibits 5-alpha-reductase type 2, the enzyme responsible for converting testosterone into dihydrotestosterone. This is important because this shift can trigger conditions such as male pattern baldness, benign prostatic hyperplasia, and prostate cancer. Indeed, increased circulating 5-alpha-reductase responds to the aging-related decline in testosterone secretion in men.

Propecia is taken by mouth for adults. BPH: 5 mg once a day. Male androgenetic alopecia: The recommended dose is 1 mg once a day. Dosage in renal insufficiency: There is no need to adjust the dose in patients with renal insufficiency but not undergoing dialysis. Dosage for the elderly: In patients over 70 years old, the elimination half-life is slightly prolonged and the clearance rate is reduced, but this has no practical clinical significance, so there is no need to reduce the dosage of the drug in the elderly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.