非那雄胺在国内上市了吗？

Tablets are 5-alpha reductase inhibitors and are the most commonly used drugs for the treatment of benign prostatic hyperplasia (BPH). They can reduce prostate size, relieve symptoms, increase urine flow rate, and delay the progression of the disease through hormone regulation mechanisms. In 1992, finasteride 5mg was launched on the market and was approved for the treatment of male prostatic hyperplasia (BPH), with the trade name Proscar.

Is finasteride available in the country?

Finasteride is a prescription drug developed and produced by Merck (known as Merke in the United States and Canada). It was approved for marketing in China in 1994.

Finasteride is a synthetic steroid compound that is a specific inhibitor of the intracellular enzyme (type II 5α reductase) involved in the metabolism of the androgen testosterone into dihydrotestosterone. Finasteride has no affinity for the androgen receptor and has no androgenic, antiandrogenic, estrogenic, antiestrogenic, or progestational effects.

Inhibition of type II 5α reductase can hinder the conversion of testosterone into the androgen dihydrotestosterone in peripheral tissues, causing a significant decrease in the concentration of dihydrotestosterone in serum and tissues. Compared with placebo, it can increase the level of testosterone in the blood circulation by about 10-15%, but it is still within the physiological range. It can quickly reduce the concentration of dihydrotestosterone in the serum and significantly reduce it within 24 hours after administration. Hair follicles contain type II 5α-reductase. In patients with male alopecia, the hair follicles in the bald area of ​​the scalp become smaller, and dihydrotestosterone increases. Administration of finasteride can reduce the concentration of dihydrotestosterone in the scalp and serum of these patients. Men with congenital deficiency of type II 5α-reductase do not suffer from male pattern baldness. These data and the results of clinical studies confirm that finasteride can inhibit the reduction of scalp hair follicles and reverse the process of hair loss.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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