Planep国内上市后多少钱？

Planep, approved in the United States in 2002, has definite efficacy in the treatment of hypertension, heart failure and myocardial infarction, has fewer adverse reactions and is well tolerated.

Planep has a protective effect on the liver, heart disease, and kidneys without damaging the organs. Planep can promote urination without losing potassium.

In 2002, Planep was approved for use in China. How much will Planep cost after it is launched in China?

It is reported that Planep is currently only used in clinical applications, but has not been officially launched in China, so we cannot provide you with a specific price!

According to Medical Companion Travel, Planep 50mg × 100 tablets from India's Lupine Pharmaceuticals costs about $500. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

Drug Metabolism of Planep:

Planep works by binding to aldosterone receptors and blocking aldosterone in the renin-angiotensin-aldosterone system (RAAS), thereby lowering blood pressure.

The average time to peak after oral administration of Planep is approximately 1.5 hours. Peak concentration (Cmax) and T area of ​​the curve (AUC) increase in proportion to the dose within the dose range of 25 to 100 mg. When the dose exceeds 100 mg, AUC becomes inversely proportional to the dose.

The plasma protein binding rate of Planep is about 50%, and it mainly binds to α1, acidic glycoprotein. In healthy volunteers and hypertensive patients, the apparent volume of distribution ranges from 43 to 90 L at steady state.

Planep is metabolized primarily by the CYP3A4 enzyme. No active metabolites have been detected in human serum, and approximately 5% of unmetabolized Planep can be detected in urine and feces. After a single oral dose of radiolabeled Planep, approximately 32% of the drug is excreted in the feces and approximately 67% of the drug is excreted in the urine. The elimination half-life of Planep is approximately 4 to 6 hours. The apparent plasma clearance is approximately 10L/h.