Planep的服用说明

Binds to mineralocorticoid receptors, thereby blocking the binding of aldosterone, a component of the renin-angiotensin-aldosterone system (RAAS). Aldosterone synthesis occurs primarily in the adrenal gland and is regulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in epithelial tissues (such as the kidneys) and non-epithelial tissues (such as the heart, blood vessels, and brain) and increases blood pressure by inducing sodium reabsorption and possibly other mechanisms.

For severe hypertension that cannot be controlled by a combination of multiple antihypertensive drugs, the addition of Planep can significantly reduce blood pressure, especially the decrease in systolic blood pressure is more significant. Combined treatment with angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers can improve patients' quality of life and reduce mortality in severe heart failure and myocardial infarction.

  For the treatment of heart failure after acute myocardial infarction, combined use with standard treatment drugs can reduce the total mortality rate in the treatment group by 15% (P=0.008); Planep is equally effective as enalapril in reversing left ventricular hypertrophy and hypertension, has fewer coughing side effects, and the combined use is more effective and has fewer adverse reactions. Except for the adverse reaction of increased blood potassium, other adverse reactions are no different from the placebo group, and there are almost no sex hormone-related side effects of spironolactone.

So how much is Planep used? 

Usual dosage for adults with congestive heart failure

1. Initial dose: 25 mg orally, once a day; and gradually increase to the target dose within 4 weeks as tolerated by the patient. 

  2. Target dose: 50 mg, orally, once a day.

Common dosages for adults with high blood pressure

1. Planep can be used alone or in combination with other antihypertensive drugs;

2. Initial dose: 50 mg, orally, once a day;

  3. Maintenance dose: 50 mg, orally, 1-2 times a day;

4. Maximum dose: 100 mg/day;

5. Obvious antihypertensive effect appears within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily.

The above are the dosage instructions. If you have any other questions, please consult your medical companion.