Planep用法以及用量

For congestive heart failure after acute myocardial infarction; for the treatment of hypertension.

  Planep contraindications

Serum potassium at the beginning is >5.5meq/L; CrCl (creatinine clearance rate) ≤30ml/min; strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, nefazodone, ditroleandomycin, clarithromycin, ritonavir, nelfinavir) are used at the same time.

The following additional contraindications apply to patients with hypertension: type 2 diabetes mellitus (non-insulin-dependent, NIDDM) with microalbuminuria; serum creatinine >2.0 mg/dL in men or >1.8 mg/dL in women; CrCl <50 mL/min; concurrent use of potassium supplements or potassium-sparing diuretics (eg, amiloride, spironolactone, triantiline).

In accordance with the Endocrine Society Clinical Practice Guidelines, its use is contraindicated in patients with Addison's disease.

Hypersensitivity to Planep or any component of the formulation; initial serum potassium >5 meq/L; severe hepatic impairment (Child-Pugh class C); clinically significant hyperkalemia; concurrent use with potassium supplements or potassium-sparing diuretics.

The following additional contraindications apply to patients with hypertension: serum creatinine >1.5 mg/dL [132 micromol/L] in men and >1.3 mg/dL [115 micromol/L] in women.

Planep usage and dosage

1. Common dosage for adults with congestive heart failure: Initial dosage: 25 mg orally, once a day; and gradually increase to the target dose within 4 weeks as tolerated by the patient. Target dose: 50 mg orally once daily.

2. Common dosages for adults with hypertension: Planep can be used alone or in combination with other antihypertensive drugs. 

3. Initial dose: 50 mg, taken orally, once a day. 

4. Maintenance dose: 50 mg, taken orally, 1-2 times a day. 

5. Maximum dose: 100 mg/day. Obvious antihypertensive effects appear within four weeks of taking the drug. Patients whose blood pressure responds inadequately to the initial dose may be increased to 50 mg twice daily. 

6. Use with caution in patients with moderate to severe liver damage. As kidney function decreases, the risk of hyperkalemia increases. Use with caution in patients with mild renal impairment; it may be disabled depending on the indications and degree of damage.