Is collagenase ointment effective? What is the mechanism of action

Collagenase ointment is indicated for debridement of chronic skin ulcers and severely burned areas. Cleaning agents such as hydrogen peroxide solution, sodium hypochlorite solution, and physiological saline can be used in conjunction with this product. Because enzymatic debridement may theoretically increase the risk of bacterial infection, systemic bacterial infection in critically ill patients should be closely monitored. When collagenase ointment (Collagenase) is applied to the surrounding tissue outside the wound, slight temporary erythema may occasionally occur, so the drug should be applied carefully to the wound. Is the treatment effective? What is the mechanism of action?

Collagenase ointment (Collagenase) treatment effect

Fifty cases of deep second-degree burn wounds were selected and randomly divided into collagenase ointment treatment group and control group. The wounds in the control group were treated with Vaseline ointment. The test results showed that the necrotic tissue clearance rate of the wounds in the collagenase ointment treatment group was significantly greater than that of the wounds in the control group, and the healing time was also shorter than that in the control group. Therefore, it can be concluded that collagenase ointment (Collagenase) can effectively remove necrotic tissue from deep second-degree burn wounds and accelerate wound healing. Collagenase ointment has a significant therapeutic effect and has a positive effect on the patient's condition. However, patients should not blindly use this drug for treatment. They should go to the hospital for a detailed physical examination before receiving treatment, and the doctor will diagnose whether they can accept collagenase ointment treatment.

Collagenase ointment's ability to digest collagen within physiological pH and temperature ranges makes it particularly effective at removing debris. Collagenase ointment (Collagenase) assists in the formation of granulation tissue and subsequent epithelialization of areas of skin ulceration and severe burns. There is no information regarding absorption of collagenase ointment (Collagenase) through the skin or its concentration in body fluids that correlates with therapeutic and/or toxic effects.

The above is an introduction to the therapeutic effect and mechanism of collagenase ointment (Collagenase). If patients want to know more drug information about collagenase ointment (Collagenase) (such as purchase channels, drug prices, etc.), they can consult the medical companion travel service at any time.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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