多替阿巴拉米片治疗艾滋病患者疗效怎么样呢？

It is a three-in-one compound drug whose main ingredients are dolutegravir 50mg + abacavir 0.6g + lamivudine 0.3g. For the treatment of adults and adolescents over 12 years old (weighing at least 40kg) infected with human immunodeficiency virus (HIV).

What is the efficacy of Dolutegra Abalamid Tablets in treating AIDS patients?

Let’s first take a look at the mechanism of action of doptabalamid tablets. Dolutegravir: It can inhibit HIV integrase by binding to the active site of integrase and blocking the strand transfer step of reverse transcription deoxyribonucleic acid (DNA) integration (a key step in the HIV replication cycle).  

Abacavir: Abacavir is a carbocyclic synthetic nucleoside analog. Abacavir is converted into the active metabolite carbavir triphosphate (CBV-TP) under the action of intracellular enzymes, which is a deoxyguanosine-5'-triphosphate (dGTP) analog. CBV-TP inhibits the activity of HIV-1 reverse transcriptase (RT) by competing with the natural substrate dGTP and inserting into viral DNA.  

Lamivudine: Lamivudine is a synthetic nucleoside analogue. Lamivudine is phosphorylated in cells to generate the active 5-triphosphate metabolite, lamivudine triphosphate (3TC-TP). The main mode of action of 3T-CTP is to terminate DNA chain synthesis by inserting nucleotide analogs, thereby inhibiting RT activity. 

To sum up, the main advantages of integrating therapeutic drugs for different stages of viral infection into the same tablet are: 1. Excellent efficacy and significant viral suppression effect; 2. The three drugs are equally effective, and both newly-treated and previously treated patients have high drug resistance barriers, which is not easy to lead to drug resistance; 3. It is easy to take and only needs to be taken once a day, without considering food effects; 4. The drug has low side effects and good tolerance, and the discontinuation rate due to drug side effects is low; 5. The metabolic pathway has few interactions with other drugs.