多替阿巴拉米片作用功效

It consists of three drugs, namely dolutegravir 50mg + abacavir 0.6g + lamivudine 0.3g. It is used to treat HIV. Many patients are not sure about its effects. Let’s take a look at it together.

The main mechanism of action of dolutegravir tablets is as follows: Dolutegravir: It can inhibit HIV integrase by binding to the active site of integrase and blocking the strand transfer step of reverse transcription deoxyribonucleic acid (DNA) integration (a key step in the HIV replication cycle). 

Abacavir: Abacavir is a carbocyclic synthetic nucleoside analog. Abacavir is converted into the active metabolite carbavir triphosphate (CBV-TP) under the action of intracellular enzymes, which is a deoxyguanosine-5'-triphosphate (dGTP) analog. CBV-TP inhibits the activity of HIV-1 reverse transcriptase (RT) by competing with the natural substrate dGTP and inserting into viral DNA. 

Lamivudine: Lamivudine is a synthetic nucleoside analogue. Lamivudine is phosphorylated in cells to generate the active 5-triphosphate metabolite, lamivudine triphosphate (3TC-TP). The main mode of action of 3T-CTP is to terminate DNA chain synthesis by inserting nucleotide analogs, thereby inhibiting RT activity.

Dolutegra abalamib tablets integrate therapeutic drugs for different stages of viral infection into the same tablet. Patients only need to take one drug to achieve the effect of combined medication. One tablet is a complete treatment plan. One tablet a day can achieve the effect of cocktail therapy without food restrictions.

It has remarkable effects and has been approved for marketing in 50 countries and regions. It has been recommended by many authoritative academic institutions and authoritative guidelines in Europe and the United States as the first-line first-line treatment for patients with HIV infection.