多替阿巴拉米片治疗艾滋病效果怎样？

It is a drug with DTG, an integrase inhibitor, as the core drug. In the real world, antiviral treatment-naïve patients treated with DTG have a lower proportion of central nervous system-related (CNS) adverse events than the four drugs RAL (Ascent), DRV/r (darunavir), EFV (efavirenz) and ATV/r (atazanavir). Therefore, the drug safety of dolutea paramid tablets with DTG integrase inhibitor as the core has been proven to be controllable. Today we are going to find out how effective Dota Abalami Tablets is in treating AIDS?

On August 27, 2014, Inbec was approved by the FDA. On January 20, 2018, ViiV, a joint venture of GlaxoSmithKline, launched Inbec, the first complete antiviral treatment plan with dolutegravir (also known as DTG in English) as the core, officially launched in China. This is also the first complete single-pill compound treatment plan in the field of HIV treatment in China.

Dolutegra is a compound preparation that can achieve the effect of combined medication by taking one drug. The antiviral effect of this drug is similar to that of tenofovir, but it has less damage to mitochondria, thereby reducing fat consumption, pancreatitis, neuritis, lactic acidosis and other adverse reactions. 

Dolutegravir, a component of dolutegravir, can inhibit HIV integrase by binding to the active site of integrase and blocking the strand transfer step of reverse transcription deoxyribonucleic acid (DNA) integration (a key step in the HIV replication cycle). Abacavir is a carbocyclic synthetic nucleoside analogue. Abacavir is converted into the active metabolite carbavir triphosphate (CBV-TP), a deoxyguanosine-5'-triphosphate (dGTP) analogue, under the action of intracellular enzymes. CBV-TP inhibits the activity of HIV-1 reverse transcriptase (RT) by competing with the natural substrate dGTP and inserting into viral DNA. Lamivudine is a synthetic nucleoside analogue. Lamivudine is phosphorylated in cells to generate the active 5-triphosphate metabolite, lamivudine triphosphate (3TC-TP). The main mode of action of 3T-CTP is to terminate DNA chain synthesis by inserting nucleotide analogs, thereby inhibiting RT activity.

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