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In January 2018, ViiV Healthcare, a joint venture of the British multinational pharmaceutical company GlaxoSmithKline (GSK), officially launched its innovative AIDS treatment drug (Inbec) in the Chinese market. Dolutegravir (Inbec) is the only three-in-one compound drug containing dolutegravir (DTG), which integrates treatment drugs for different stages of viral infection in the same tablet. Patients only need to take one drug to achieve the effect of combined medication.

Dolutegravir tablets (Inbec) are compound preparations. Each tablet contains dolutegravir sodium (calculated as dolutegravir) 50 mg, abacavir sulfate (calculated as abacavir) 600 mg and lamivudine 300 mg. It is suitable for the treatment of infections with human immunodeficiency virus (HIV).

One of the ingredients in Dolutegra, abacavir, may cause a hypersensitivity reaction. The most common symptoms of a hypersensitivity reaction are: fever (high fever) and rash. Other common reactions include: nausea (feeling like you are throwing up), vomiting, diarrhea, abdominal pain, and tiredness. May also include: joint or muscle pain, neck swelling, shortness of breath, sore throat, cough, occasional headache, eye inflammation (conjunctivitis), mouth sores, low blood pressure, and numbness in the hands and feet. Hypersensitivity reactions can occur at any time during treatment with Trimax, but are more common during the first 6 weeks of treatment.

In individual patients, the most serious adverse events that may be associated with dolutegravir and abacavir/lamivudine are hypersensitivity reactions, including rash and severe hepatic effects. An analysis of pooled data from Phase IIb to IIIb clinical trials found that the adverse reactions observed with the combination of dolutegravir + abacavir/lamivudine were generally consistent with the adverse reaction profiles of the single ingredients dolutegravir, abacavir, and lamivudine. It should not be used in patients with hypersensitivity reactions to dolutegravir, abacavir, and lamivudine or any excipients.