多替阿巴拉米片的作用

When a patient develops the human immunodeficiency virus, which is the so-called HIV that everyone is afraid of, they must be treated in time, otherwise it will threaten the body's health. It is one of the drugs to treat this disease. So what is the role of Duotie Abalamid Tablets?

The three active ingredients contained in Dolutegra Abalamid Tablets play their respective roles. Dolutegravir: Can inhibit HIV integrase by binding to the active site of integrase and blocking the strand transfer step of reverse transcription deoxyribonucleic acid (DNA) integration (a key step in the HIV replication cycle). Abacavir: Abacavir is a carbocyclic synthetic nucleoside analog. Abacavir is converted into the active metabolite carbavir triphosphate (CBV-TP) under the action of intracellular enzymes, which is a deoxyguanosine-5'-triphosphate (dGTP) analog. CBV-TP inhibits the activity of HIV-1 reverse transcriptase (RT) by competing with the natural substrate dGTP and inserting into viral DNA. Lamivudine: Lamivudine is a synthetic nucleoside analogue. Lamivudine is phosphorylated in cells to generate the active 5-triphosphate metabolite, lamivudine triphosphate (3TC-TP). The main mode of action of 3T-CTP is to terminate DNA chain synthesis by inserting nucleotide analogs, thereby inhibiting RT activity.

Judging from a large number of clinical trial data, DTG has a low discontinuation rate due to adverse drug reactions (ADR) or virological failure, which are 5.8% and 0.5% respectively. The ADR drops significantly after one year of taking the drug. The most common adverse reactions are gastrointestinal dysfunction, mental disorders and neurological disorders, but the adverse reaction rates are less than 1.5%. From the comparison with patients who failed the first-line regimen of RAL (Ascent) and EVG (Evitegravir), the other two integrase inhibitors, the number of drug-resistant mutations in dolutea palamid tablets is significantly less than that of the other two drugs, making it less likely to develop drug resistance. In the real world, antiviral treatment-naïve patients treated with DTG have a lower proportion of central nervous system-related (CNS) adverse events than RAL (Ascent), DRV/r (darunavir), EFV (efavirenz) and ATV/r (atazanavir). Therefore, the drug safety of dolutea paramid tablets, which is based on DTG integrase inhibitors, has proven to be controllable. In general, it must have four outstanding advantages: 1. Excellent efficacy and significant viral suppression effect; 2. The three drugs are equivalent in equivalence, and both newly-treated and previously treated patients have a high resistance barrier, which is not easy to lead to drug resistance; 3. It is easy to take, only needs to be taken once a day, and there is no need to consider food effects; 4. The drug has low side effects, good tolerability, and a low discontinuation rate due to drug side effects; 5. There are few interactions between metabolic pathways and other drugs.