吃绥美凯能活多久？

It is the first three-drug single-pill compound preparation to be launched in China. It was announced to be launched in my country at the same time in Beijing, Shanghai and Zhengzhou on January 20, 2018. The characteristics of this product are: rapid onset, long-lasting effect; high drug resistance barrier; easy to take; no food restrictions. The generic name of Suimeikai is Duotie abalami tablets; the trade names are: Suimeikai; TRIUMEQ. Suitable for HIV-infected adults and adolescents over 12 years old (weighing at least 40kg). If possible, the HLA-B*5701 allele should be tested. If you carry the HLA-B*5701 allele, you should not take ABC-containing drugs.

Each tablet of Trimax contains 50 mg of dolutegravir (DTG), 600 mg of abacavir (ABC) and 300 mg of lamivudine (3TC). Suimeikai should be taken orally under the guidance of a physician with experience in treating HIV infection. This product is not affected by food. One tablet at a time, once a day. It is not recommended for those whose creatinine clearance is less than 50ml/min.

Dolutegravir, the active ingredient of Trimax, can inhibit HIV integrase by binding to the active site of integrase and blocking the strand transfer step of reverse transcription deoxyribonucleic acid (DNA) integration (a key step in the HIV replication cycle). The other active ingredient, abacavir, is a carbocyclic synthetic nucleoside analog. Abacavir is converted into the active metabolite carbavir triphosphate (CBV-TP) under the action of intracellular enzymes, which is a deoxyguanosine-5'-triphosphate (dGTP) analog. CBV-TP inhibits the activity of HIV-1 reverse transcriptase (RT) by competing with the natural substrate dGTP and inserting into viral DNA. Another active ingredient, lamivudine, is a synthetic nucleoside analog. Lamivudine is phosphorylated in cells to generate an active 5-triphosphate metabolite, lamivudine triphosphate (3TC-TP). The main mode of action of 3T-CTP is to terminate DNA chain synthesis by inserting nucleotide analogs, thereby inhibiting RT activity. The mechanism of action of Suimeikai can be said to go directly to the focus of the disease, and the curative effect is also very significant. However, there is no accurate data on how long one can live after taking it. It varies according to the patient's system and the degree of disease progression.