非达霉素(Dificid)的副作用和不良反应

In addition to its desired effects, fidaxomicin (Dificid) may cause some unwanted side effects. Although not all of these side effects will occur, if they do, they may require medical attention.

Side effects of fidaxomicin (Dificid) seek medical attention immediately

1. Less common side effects

Abdominal or stomach pain; bloating; bloody or black tarry stools; chills; confusion; cough; drowsiness; fever; loss of appetite; lower back or flank pain; muscle tremors; nausea; painful or difficult urination; pale skin; rapid and deepening of breathing; restlessness.

Severe constipation; shortness of breath; sore throat; stomach cramps; difficulty breathing with exertion; ulcers, sores, or white spots in the mouth; unusual bleeding or bruising; unusual tiredness or weakness; vomiting; vomiting blood or a substance that looks like coffee grounds.

2. Other side effects

Some side effects usually do not require medical attention. These side effects may go away during treatment as your body adjusts to the medication. Additionally, your health care professional may tell you how to prevent or reduce some side effects.

The pictures come from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Consult your doctor immediately about side effects of fidaxomicin (Dificid)

Less common side effects

Bloating or tenderness in the abdomen or stomach; excess stomach acid or acid reflux; burping; blurred vision; difficulty swallowing; Dry mouth; excess gas in the stomach or intestines; flushed, dry skin; fruity-smelling breath; feeling of fullness; heartburn; increased appetite; increased thirst; increased urination; indigestion; flatulence; stomach upset or discomfort; sweating; difficulty breathing; unexplained weight loss.

Side Effect Management for Medical Professionals

1. Gastrointestinal adverse events

(1), very common (10% or more): nausea (up to 11%).

(2) Common (1% to 10%): vomiting, abdominal pain, diarrhea, constipation, gastrointestinal bleeding, and upper abdominal pain.

(3) Uncommon (0.1% to 1%): abdominal distension, flatulence, dry mouth.

(4). Frequency not reported: abdominal tenderness, indigestion, dysphagia, intestinal obstruction, megacolon, lower abdominal pain.

2. Metabolism related

(1) Common (1% to 10%): hypokalemia, hyperkalemia, hypomagnesemia.

(2) Uncommon (0.1% to 1%): anorexia and decreased appetite.

(3). Frequency not reported: hyperglycemia, metabolic acidosis.

3. Nervous system

(1), common (1% to 10%): headache, dizziness.

(2) Uncommon (0.1% to 1%): taste disorder.

4. Others

(1) Common (1% to 10%): fever, peripheral edema, fatigue.

(2) Uncommon (0.1% to 1%): Chills.

(3). Frequency not reported: alkaline phosphatase increased, blood bicarbonate decreased.

5. Genitourinary system

Common (1% to 10%): urinary tract infection.

6. Blood system

(1) Common (1% to 10%): anemia, neutropenia.

(2). Frequency not reported: decreased platelet count.

7. Hypersensitivity reaction

Post-marketing report: Hypersensitivity reaction (dyspnea, angioedema, rash, itching).

8. Respiratory system

Common (1% to 10%): dyspnea, pneumonia.

9. Mental system

Common (1% to 10%): insomnia.

10. Cardiovascular system

Common (1% to 10%): Hypotension.

11. Skin system

(1) Common (1% to 10%): itching.

(2) Uncommon (0.1% to 1%): rash.

(3). Frequency not reported: drug rash, urticaria, follicular rash, maculopapular rash, exfoliative rash.

12. Musculoskeletal system

Common (1% to 10%): back pain.

13. Liver system

(1), uncommon (0.1% to 1%): Elevated alanine aminotransferase (ALT).

(2). Frequency not reported: elevated liver enzymes and elevated aspartate aminotransferase (AST).