盐酸阿考替胺片的功效与副作用

Functional dyspepsia (FD), one of the most common gastrointestinal diseases, is a chronic and heterogeneous condition that has a significant impact on patients' quality of life and imposes considerable socioeconomic costs. In fact, the annual global incidence of FD is estimated to be 1-6%. In the United States, it is estimated that approximately 5% of all primary care visits involve functional dyspepsia, with associated costs of approximately $1 billion per year. In Asia, FD is usually 2-3 times more common than irritable bowel syndrome (IBS). FD prevalence appears to be high in Iran as well, ranging from 0.1% to 29.9%. Acotiamide hydrochloride is a new muscarinic M1 and M2 receptor antagonist developed by Japan's Zeria New Pharmaceutical Co., Ltd. It was launched in Japan in February 2013 and became the world's first FD treatment drug. So, what are its efficacy and side effects?

Efficacy of acotiamide hydrochloride tablets

Acotiamide hydrochloride tablets were first developed by Japan's Zeria New Pharmaceutical Co., Ltd. and later jointly launched in Japan by Astellas Pharmaceuticals and Zeria Pharmaceuticals. Acotiamide hydrochloride oral tablets work in the digestive tract mainly by inhibiting acetylcholinesterase, which can promote gastric motility, improve gastric accommodation disorders, and enhance gastric fundus dilation. At present, Japan has conducted a number of clinical studies on acotiamide hydrochloride tablets, such as breath test, ultrasound test and TQT test, etc., which have proved that this product can significantly improve the symptoms of FD, is highly safe, and can still maintain the improvement effect after discontinuing the drug, and is not easy to develop drug resistance after repeated administration.

Acotiamide hydrochloride tablets side effects

Mainly urticaria, constipation, rash, vomiting, nausea, diarrhea, etc. were observed in multiple trials.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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