kaftrio的副作用及其处理措施？

The side effects of kaftrio include headache, diarrhea, rhinorrhea, elevated alanine aminotransferase, nasal congestion, upper respiratory tract infection, etc. Patients can alleviate these symptoms by paying attention to diet, adjusting lifestyle, medication, and adjusting medication regimen.

About

Kaftrio is a drug that treats cystic fibrosis. It can correct the genetic defects of cystic fibrosis patients, improve symptoms and reduce disease progression by repairing defects in the CFTR gene and improving the function of ion channels. Cystic fibrosis is a common genetic disease. Kaftrio is an oral drug that is a CFTR modulator. According to some reports, Kaftrio can significantly reduce symptoms, especially lung infections, and prevent patients from losing lung function.

kaftrio

The most common adverse drug reactions of kaftrio are headache, abdominal pain, diarrhea, nasal congestion, increased aspartate aminotransferase, rash, increased alanine aminotransferase, increased blood creatine phosphokinase, rhinorrhea, rhinitis, influenza, sinusitis, upper respiratory tract infection, and increased blood bilirubin.

Other adverse reactions that occurred with kaftrio with a frequency of 2%-5% and ≥1% higher than placebo included gas, bloating, dizziness, dysmenorrhea, conjunctivitis, urinary tract infection, increased c-reactive protein, pharyngitis, respiratory infection, tonsillitis, hypoglycemia, acne, eczema, and pruritus.

Measures to deal with side effects

1. Headache: Patients should ensure adequate rest and can use distraction methods, such as deep breathing or meditation, to relieve tension headaches. For migraines or other types of headaches, different measures may be needed, such as taking painkillers or visiting a hospital.

2. Upper respiratory tract infection: Pay attention to rest, keep the indoor air fresh, avoid pungent odors, maintain hand hygiene, avoid contact with eyes and nose, and properly replenish water and vitamins. If symptoms are severe, such as fever, cough, sore throat, etc., you can take medication as directed by your doctor.

3. Abdominal pain: Patients who experience abdominal pain while taking Kaftrio should eat reasonably, which can reduce the mechanical and chemical stimulation of the abdomen by food and relieve pain. For example, avoid irritating condiments, tobacco, alcohol, etc., and adopt a diet of small and frequent meals. Non-irritating, low-fiber, easily digestible, high-protein foods such as milk, eggs, soy milk, etc. should be eaten at regular times and in a quantitative manner.

4. Diarrhea: Pay attention to replenishing water and salt to avoid dehydration. In addition, you can take some home remedies, such as taking probiotics, avoiding dairy products and high-fiber foods, avoiding abdominal cold, and avoiding raw and cold foods, such as ice cream and cold drinks. If symptoms are severe or persistent, seek medical attention immediately.

5. Skin rash: If a rash occurs during Kaftrio treatment, attention should be paid to keeping the skin clean and dry, and avoiding friction and scratching. If symptoms are severe or persistent, you should seek medical treatment immediately and adjust the drug dosage or discontinue the drug according to the doctor's evaluation and switch to other drugs.

6. Nasal congestion: You can take some non-drug therapies, such as using a humidifier, using saline nasal drops to clean the nasal cavity, and other measures to relieve it. Moderately increase the amount of water you drink to keep the stool clear. For severe nasal congestion, massage the Yingxiang and Bitong points.

7. Rhinorrhea: Care should be taken to avoid allergens such as pollen, dust mites, etc. It can be treated with allergy medications or steroid nasal sprays.

8. Rhinitis: It can be treated with anti-allergic drugs or steroid nasal sprays. In severe cases, immunotherapy or surgery may be considered.

9. Influenza: Pay attention to rest and replenish fluids, and take preventive measures, such as washing hands frequently and avoiding contact with sick people. If symptoms are severe or persistent, seek medical attention immediately.

10. Sinusitis: It can be treated with antibiotics and steroid nasal sprays. If symptoms are severe or persistent, surgery should be considered.

In short, different treatment measures may be different for different side effects. If patients experience the above side effects during Kaftrio treatment, they should consult a doctor in time and deal with them to prevent the side effects from worsening and affecting their health.

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