诺华地拉罗司用法用量

(Deferasirox) is a new oral iron chelator. It is the first oral iron chelator approved by the US FDA for routine use. It is approved for use in patients ≥2 years old with chronic iron overload caused by blood transfusion. In Europe, it is recommended as a first-line drug for patients with thalassemia iron overload over 6 years old. Iron chelators can also be given to patients undergoing ASCT when iron overload occurs; deferasirox can also be used to treat patients with reversible renal insufficiency caused by Fanconi syndrome.

The common starting dose of Novartis deferasirox is 20 mg/(kg·d). If there is massive blood transfusion, the iron increase is >0.5 mg/(kg·d) or the iron load before treatment is high, the recommended dose is 30 mg/(kg·d), the iron increase is <0.3 mg/kg, and 10-15 mg/(kg·d) is enough to control the disease. It should be administered on an empty stomach 30 minutes before meals and should be completely dissolved in water or apple juice or orange juice and taken together.

Lower doses of deferasirox [5-10 mg/(kg·d)] can only be used in young patients with mild iron overload and few blood transfusions, or in elderly patients who have not received satisfactory results from chelation therapy in the past; patients who use deferasirox 20 and 30 mg/(kg·d) need to carefully monitor body iron stores, because 50% and 10% of patients can still continue to increase their body iron levels. In addition, the frequency of blood transfusion can also affect the effect of deferasirox in controlling liver concentration. When the iron intake is greater than 0.5 mg/(kg·d), only 47% of patients who receive the same dose of deferasirox have a reduction in liver concentration.

Swiss Novartis is an enterprise with a long history and good reputation in the industry. As a leader in the industry, its work focuses on the field of health care and medicine, and its business involves preventive vaccines, diagnostic reagents, innovative drugs and health care consumer products. When patients take Novartis, they can only benefit if they take the medication correctly.

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