地拉罗司（恩瑞格）适应症及服用方法

(Enrig) is an iron chelator product developed by the Swiss pharmaceutical company Novartis. It is the first oral iron-removing agent approved by the U.S. FDA for routine use. The application of iron chelators has greatly reduced the mortality rate and improved the quality of life of patients with long-term blood transfusions. Its clinical application has always received widespread attention and attention. Today we will learn more about the indications and administration methods of Deferasirox (Enrige).

The US FDA approves the new drug Deferasirox for indications: (1) For the treatment of chronic iron overload (CIO) caused by blood transfusion therapy in patients 2 years old and above; (2) For the treatment of chronic iron overload (CIO) in patients with non-transfusion-dependent thalassemia syndrome (NTDT) aged 10 years and above. Starting dose:

1. The recommended starting daily dose of Deferasirox (Enrige) is 20 mg/kg.

2. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (i.e., more than 4 units/month for adults) and need to reduce excessive iron exposure, a starting dose of 30 mg/kg/day may be considered. 3. For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month for adults) and who need to maintain iron balance in the body, a starting dose of 10 mg/kg/day may be considered.

4. For patients who have already responded well to deferoxamine treatment, the initial dose of deferasirox (Enrige) may be considered to be half the dose of deferoxamine. (For example, a patient receiving deferoxamine 40 mg/kg/day, 5 days per week, or equivalent, may start at 20 mg/kg if switched to Enriga.) How to take: Deferasirox should be taken once daily on an empty stomach, at least 30 minutes before a meal, preferably at the same time each day. Tablets should not be chewed or swallowed whole. Deferasirox (Enreg) should not be taken with aluminum-containing antacids, and the dose (mg/kg) needs to be calculated and rounded to the nearest whole tablet.

Completely dissolve the tablets in water, apple juice or orange juice (100-200mL) by stirring until a clear suspension is obtained and then drink it. The remaining medicine must be added with a small amount of water, apple juice or orange juice and mixed well before taking. It is not recommended that deferasirox be dissolved in carbonated beverages or milk because it can cause foaming and slow dispersion.

The above is the content of how to take (Enrige), I hope it can help you!

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