Desirox作用效果

It is used to treat chronic iron overload in patients with β-thalassemia older than 6 years old due to frequent blood transfusions (monthly administration of concentrated red blood cells ≥7mL/kg). So, what is the effect of Desirox?

What Desirox does:

Chronic iron overload is a serious symptom, and organ failure can occur due to the iron deposits produced. When the heart or liver is affected, the condition can be life-threatening. Iron overload is treated by administering iron chelators, which drive iron deposits into soluble complexes that can be excreted from the body. Many patients, such as those with thalassemia, sideroblastic anemia, myelodysplastic syndrome and aplastic anemia, require long-term dependence on blood transfusion treatment, which leads to increased iron deposition in the body and secondary transfusion-related iron overload, which causes tissue damage and functional damage to multiple organs. Cardiac complications including myocardial infarction, congestive heart failure, and arrhythmia are the most common causes of death.

Iron chelators are a new type of iron removal treatment based on directional binding of iron ions in the body, effectively increasing iron excretion, reducing iron content in the body and its pathological deposition in various organs. It is currently the only effective drug for the treatment of iron overload. The application of iron chelators has greatly reduced the mortality and improved the quality of life of patients with long-term blood transfusions, and its clinical application has been receiving widespread attention and attention. The iron chelators currently used in clinical practice mainly include deferoxamine DFO, deferiprone DFP, and deferasirox.

Effects of Desirox:

Studies have shown that it has good safety and tolerability, can significantly reduce the iron load on the heart and liver, and is easily accepted by patients. At the same time, it also has pharmaceutical properties such as antifungal (such as Mucor that grows in an iron-rich environment), anti-cell proliferation, anti-malarial, anti-oxidative stress damage, anti-cytotoxic-induced apoptosis, etc.; it can be used for the treatment of secondary hemochromatosis, porphyria cutanea tarda and other diseases.