恩瑞格推荐的使用量是多少？

The chemical name is 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid. Enrig is an iron chelator product developed by the Swiss pharmaceutical company Novartis. Enrig is the first oral iron-depleting agent approved by the US FDA for routine use. It is approved for use in patients ≥2 years old with chronic iron overload caused by blood transfusion. In Europe, it is recommended as a 6- As a first-line drug for patients with thalassemia iron overload over the age of 18, clinical research is currently underway in China; Phase II and III clinical trials and pharmacokinetic studies have shown that it has good safety and tolerability, can significantly reduce iron load in the heart and liver, and is easily accepted by patients. At the same time, it also has pharmaceutical properties such as antifungal (such as Mucor that grows in an iron-rich environment), anti-cell proliferation, anti-malarial, anti-oxidative stress damage, anti-cytotoxic-induced apoptosis, etc.; it can be used for the treatment of secondary hemochromatosis, porphyria cutanea tarda and other diseases.

The recommended starting daily dose of Enrig is 20 mg/kg. For patients who receive more than 14 mL/kg of packed red blood cells per month (i.e., more than 4 units/month for adults) and need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered; for patients who receive less than 7 units per month Patients who require mL/kg packed red blood cell (i.e., less than 2 units/month for adults) transfusions and who need to maintain iron balance in the body may consider an initial dose of 10 mg/kg/day; patients who have already responded well to deferoxamine treatment may consider an initial Enrig dose equivalent to half the deferoxamine dose. (For example, a patient receiving deferoxamine 40 mg/kg/day, 5 days per week, or equivalent, could start at 20 mg/kg if switched to Enriga.

How to take Enrige should be taken on an empty stomach at least 30 minutes before meals, once a day, preferably at the same time every day. The tablets cannot be chewed or swallowed whole; Enrige must not be taken with aluminum-containing antacids. The dosage (mg/kg) needs to be calculated and rounded to the nearest whole tablet; completely dissolve the tablets in water, apple juice or orange juice (100-200mL) by stirring until a clear suspension is obtained and then drink it. The remaining medicine must be added with a small amount of water, apple juice or orange juice and mixed before taking. Not recommended for dissolution in carbonated drinks or milk as it can cause foaming and slow dispersion.