恩瑞格国内去哪里购买呢?
Mechanism of action DFS has pharmacological effects such as antifungal effects (such as Mucor mold that grows in iron-rich environments), anti-cell proliferation, anti-malaria, anti-oxidative stress damage, anti-cytotoxicity-induced apoptosis, etc.
1. DFS and fungal infection: Iron is a substance that fungi rely on for survival, and it plays a very important role in the growth and toxicity of fungi. The antifungal effect of iron chelators may lie in their removal of iron necessary for fungal growth, thereby achieving the purpose of treating fungal infections.
2. DFS and cell proliferation: Iron plays a very important role in the process of cell proliferation, and iron chelators may have anti-cell proliferation properties. This suggests that iron chelators may become a new type of anti-cancer agent for the treatment of tumors.
The commonly used starting dose of Enrig is 20 mg/(kg·d). If there is a large amount of blood transfusion and the iron increase is >0.5 mg/(kg·d) or the iron load before treatment is high, the recommended dose is 30 mg/(kg·d). If the iron increase is <0.3 mg/kg, 10-15 mg/kg/d is enough to control the condition. Administer on an empty stomach 30 minutes before meals and should be completely dissolved in water or apple or orange juice. Lower doses of deferasirox [5-10 mg/(kg·d)] can only be used in young patients with mild iron overload and few blood transfusions, or in elderly patients who have not received satisfactory results from chelation therapy in the past; patients using Enrig 20 and 30 mg/(kg·d) need to carefully monitor body iron stores, because body iron levels may continue to rise in 50% and 10% of patients. In addition, the frequency of blood transfusion can also affect the effect of Enrige in controlling liver concentrations. When the iron intake is greater than 0.5 mg/(kg·d), only 47% of patients who receive the same dose of deferasirox have a reduction in liver concentrations.
Enrig has been approved for sale in my country, and patients can buy it at large domestic hospitals or pharmacies with a prescription, but the price is high. The patient chose Indian Enrig, which is extremely cost-effective. In addition to going to India in person, he can also consult through medical companion travel, a professional overseas medical service organization in China.
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