地拉罗司推荐用量是多少呢？

Thalassemia, a genetic disease, has become more and more common among people in southern my country. This genetic disease is not simply anemia. Moderate to severe thalassemia often kills patients. Our current most effective drug for treating thalassemia is produced by Novartis. What is the recommended dosage of deferasirox?

The recommended starting daily dose of deferasirox is 20 mg/kg. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (ie, more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered. For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered. In patients who have already responded well to deferoxamine therapy, an initial dose equivalent to half the deferoxamine dose may be considered. (For example, a patient receiving deferoxamine 40 mg/kg/day 5 days per week or equivalent may start at 20 mg/kg if switched to deferasirox.)

The dosage adjustments are as follows. Myelosuppression: Interrupt treatment; may restart once cause of cytopenias is determined; Contraindicated if platelet count <50,000/mm Cutaneous Toxicity: Rash (severe): Interrupt treatment; may reintroduce at lower doses (with future dose escalations) and short-term oral corticosteroids. Serious skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme): Stop and evaluate. Gastrointestinal: Discontinue treatment for suspected gastrointestinal ulceration or bleeding. Hearing loss or visual impairment: Consider dose reduction or treatment interruption.

Finally, we would like to remind all patients that some serious hypersensitivity reactions may occur during use. Although the probability is unlikely, they usually occur within the first month of treatment. If reaction is severe, discontinue treatment and do not reintroduce patients with previous hypersensitivity reactions due to risk of anaphylactic shock. If you have any discomfort while taking the medicine, you should pay attention to it. Do not wait until serious complications appear to take it seriously.