恩瑞格多少钱一盒呢？

(DFS, ICL670) is currently the only oral iron chelator developed by Novartis. It was approved by the FDA in November 2005 for use in patients 2 years and older with chronic iron overload caused by blood transfusions. In December 2012, Enrig was approved by the European Commission for the treatment of chronic iron overload in patients aged 10 years and above with non-transfusion-dependent thalassemia (NTDT) syndrome who require chelation therapy due to contraindications or insufficiency of deferoxamine mesylate therapy. On January 23, 2013, the FDA approved the new indication of Enriga for the treatment of chronic iron overload in patients with non-transfusion-dependent thalassemia (NTDT) aged 10 years and above.

Clinical studies have shown that 42.7% of patients achieved hematological response and reduced the need for blood transfusions after receiving DFO or Enrega chelation therapy. There may be a dynamic, bidirectional regulatory mechanism between erythropoiesis and iron overload. On the one hand, ineffective erythropoiesis can lead to increased intestinal iron absorption through reduced hepcidin secretion by the liver. On the other hand, chelation treatment of iron overload can improve erythropoiesis, increase hemoglobin levels, and reduce clinical blood transfusions.

The treatment effect of Enrig is so good, how much does it cost?

The price is different in every place, and as long as it is a different pharmacy, the price will still be different. The price of Enrig in China is relatively high, with a box costing about $2,000. The dosage method is to take 20mg to 40mg Enreg/Delasirox for 1kg of body weight. Taking 30mg/kg as an example, for a normal person weighing 60kg, the cost of taking Desirox for a month is more than 24,000$. This price is acceptable to ordinary families.

Enriga, produced by cipla in India, has a specification of 500mg*30 tablets/box and sells for about RMB 500. The original drug Enriga launched by Novartis in India has a specification of 400mg*30 tablets/box, and the price is equivalent to RMB 700.

The recommended starting daily dose is 20 mg/kg. For patients who receive monthly transfusions of more than 14 mL/kg of packed red blood cells (i.e., more than 4 units/month in adults) and who need to reduce excess iron exposure, a starting dose of 30 mg/kg/day may be considered. For patients who receive monthly transfusions of less than 7 mL/kg of packed red blood cells (i.e., less than 2 units/month in adults) and who need to maintain body iron balance, a starting dose of 10 mg/kg/day may be considered.