去纤苷的治疗效果好吗？会有哪些副作用

Defibrotide is currently recognized as the most promising new drug for the treatment of hepatic veno-occlusive disease (HVOD) after hematopoietic stem cell transplantation (HSCT). This drug can reduce the adhesion of leukocytes to vascular endothelial cells and reduce the inflammatory damage of endothelial cells by reducing the expression of cell adhesion molecules on the surface of endothelial cells. Is the treatment effective? What are the side effects?

In a phase 2 trial of 75 patients, 44% survived 100 days after transplantation. In a phase 3 trial of 102 patients, 38% survived 100 days after transplantation. In an additional 351 In expanded trials of patients, 45% survived 100 days after transplantation, all of whom were diagnosed with hepatic veno-occlusive disease (HVOD) and associated renal or pulmonary dysfunction after hematopoietic stem cell transplantation (HSCT). The estimated 100-day survival rate for patients with severe hepatic veno-occlusive disease (HVOD) without defibrotide treatment is 21%-31%. It can be seen that defibrotide has a significant effect in the treatment of hepatic veno-occlusive disease (HVOD). The use of this drug effectively prolongs the survival time of patients and has a positive effect on the patient's condition.

Defibrotide side effects

Side effects of defibrotide include: hypotension, diarrhea, vomiting, nausea, nose bleeding, abdominal cramps, etc. Defibrotide side effects are generally mild. In daily life, if patients want to minimize the degree of side effects, they must first strictly follow the doctor's instructions during medication and use medication under the guidance of a doctor. If patients experience serious side effects during Defibrotide treatment, they should stop taking the drug and seek medical help in time. The doctor will propose the best treatment plan based on the patient's condition. Patients should not take medication blindly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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