去纤苷是哪国的药？

Defibrotide was developed by Gentium Pharmaceuticals of Italy. After Gentium Pharmaceuticals was acquired by Jazz Pharmaceuticals of the United States, it was approved for sale in the United States by the U.S. Food and Drug Administration (FDA) on March 30, 2016.

Studies have shown that defibrotide exerts various biological functions mainly by affecting vascular endothelial cell response and platelet activity. Defibrinoside contains nucleic acid aptamers that interact with adenosine A1 and A2 receptors, thereby reducing the response of endothelial cells to injury and protecting vascular endothelium. In vitro experiments and in vivo animal experiments have confirmed that defibrotide can stimulate the release of prostacyclin PGI2. PGI2 is mainly synthesized and secreted by vascular endothelium and platelets. It dilates blood vessels and inhibits platelet aggregation by increasing the level of cAMP. Elevated PGI2 can also inhibit the lipoxygenase pathway to reduce the production of leukotriene LTB4 and reduce ischemia-induced tissue damage. Compared with large blood vessels, a series of biological activities of defibrotide are mainly produced against small blood vessels.

Currently (Defibrotide) is not on the market in China, so it will not be included in China's medical insurance catalog to provide everyone with preferential medical insurance policies. Patients who want to purchase defibrotide can only go abroad to purchase defibrotide at their own expense. However, as we all know, the price of original drugs is very expensive, and a lot of manpower and material resources are consumed in the process of purchasing drugs, which puts huge pressure on patients. Therefore, more people choose to purchase drugs overseas to obtain the drugs they need. According to what Medical Companion Travel currently knows, the specification of defibrinoside is 200 mg, and the price is about $21,600. It is more suitable for patients to use for a long time, is high quality and low price, and saves worry and effort. The exchange rate in the market often fluctuates, and the price is not always fixed, but will change with the exchange rate. For more information about defibrotide, please contact Medical Travel for details.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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