去纤维钠多少钱一支？在哪买？

Hepatic veno-occlusive disease (HVOD) is one of the serious complications after hematopoietic stem cell transplantation (HSCT), and the mortality rate in patients with severe HVOD can be as high as 100%. Defibrotide is a single-stranded oligonucleotide mixture that has anti-thrombotic and fibrinolytic effects. In recent years, multiple clinical research results have shown that Defibrotide is a safe and effective drug for preventing and treating HVOD after HSCT. Defibrotide is an adenosine receptor agonist with multiple effects. The adenosine A1/A2 receptors of endothelial cells are involved in the regulation of endothelial cells and the response of endothelial cells to injury. Defibrotide can act on these receptors to produce a variety of downstream effects.

Defibrotide can also reduce the expression of cell adhesion molecules on the surface of endothelial cells, thereby reducing the adhesion of leukocytes to vascular endothelial cells and reducing the inflammatory damage of endothelial cells. In addition, Defibrotide can also promote the release of prostaglandin I2 (PGI2) and prostaglandin E2 (PGE2), thereby causing blood vessel dilation, inhibiting platelet aggregation, and reducing ischemic damage. Studies have shown that Defibrotide can significantly increase the expression of thrombomodulin (TM) and tissue factor pathway inhibitors to produce anticoagulant effects.

Treatment with Defibrotide will also produce certain side effects or adverse reactions. The most common side effects of this drug include: hypotension/diarrhea/vomiting/nausea/nose bleeding, etc. The incidence rate of grade 3-4 reactions related to defibrotide is 7%, mainly hypotension/pulmonary and gastrointestinal bleeding/abdominal cramps, etc. The side effects of Defibrotide are usually mild, and patients do not need to worry too much.

Concomitant use of Defibrotide and a systemic anticoagulant or fibrinolytic therapy may increase the risk of bleeding. Discontinue anticoagulants and fibrinolytics before defibrotide treatment, and consider delaying initiation of defibrotide administration until the effects of the anticoagulants have lessened.

How much does one cost? Where to buy? It is understood that Defibrotide, produced by Irish Jazz Pharmaceuticals, has a specification of 200mg and a price of about $21,600. Since the exchange rate floating price is not fixed, if patients want to know the specific price information of this drug, or if they want to purchase the cost-effective Defibrotide overseas, they can consult with domestic reliable overseas medical service companies (such as Medical Travel).

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician. 

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