爱尔兰爵士制药的去纤苷一支的价格

(Defibrotide) has anti-thrombosis, promoting fibrinolysis, anti-ischemia, anti-infection and other effects in vivo and in vitro. Defibrotide sodium is an adenosine receptor agonist with multiple effects. The adenosine A1/A2 receptors of endothelial cells are involved in the regulation of endothelial cells and the response of endothelial cells to injury. Defibrotide sodium can act on these receptors to produce a variety of downstream effects.

Defibrinated sodium can also reduce the expression of cell adhesion molecules on the surface of endothelial cells, thereby reducing the adhesion of leukocytes to vascular endothelial cells and reducing the inflammatory damage of endothelial cells. In addition, defibrinated sodium can also promote the release of prostaglandin 12 (PGl2) and prostaglandin E2 (PGE2), thereby causing vasodilation, inhibiting platelet aggregation, and reducing ischemic damage.

Irish Jazz Pharmaceuticals' defibrotide has not yet been approved for domestic marketing, so patients currently have to purchase drugs overseas to meet their actual treatment needs. It is understood that the drug Defibrotide under Irish Jazz Pharmaceuticals has a specification of 200mg and the price of each tube is about $22,000. Patients in need can not only go abroad to purchase the required drugs in person, but they can also contact some professional and formal overseas medical service organizations in China (such as Medical Companion Travel) to obtain their specific drug purchase channels.

In different clinical studies, the time for preventive use of defibrotide is not all the same. It is first started before pretreatment and lasts until 20 to 30 days after transplantation. Some studies suggest that the preventive application of defibrotide may reduce the incidence of aGVHD, but further clinical studies are needed to confirm this. Irish Jazz Pharmaceuticals is a specialty pharmaceutical company focused on the identification, development and commercialization of pharmaceutical products. Automation of activities brings consistency in quality to the company's products and enables the company to scale up and down based on market demand conditions. As one of its products, it has broad market prospects.

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