爱尔兰爵士制药去纤苷怎么购买？

(Defibrotide) is a mixture of single-stranded oligonucleotides decomposed from genomic DNA from calf lungs or pig intestinal mucosa. The oligonucleotide chain lengths of this drug vary, and the relative molecular mass ranges from 15×10³ to 30×10³. Its purine to pyrimidine ratio is greater than 0.85. Studies have shown that defibrinated sodium can significantly increase the expression of thrombin regulatory protein (TM) and tissue factor pathway inhibitor (TFPI), thereby producing anticoagulant effects. In some inflammatory and ischemic diseases, the imbalance between cathepsin G and its physiological inhibitors can lead to tissue cell destruction and platelet aggregation. Defibrotide sodium can bind to cathepsin G and inhibit its function.

Foreign researchers cultured vascular endothelial cells in a matrix containing plasma from patients after autologous HSCT (HSCT). The results showed that defibrinated sodium can increase the expression of intercellular adhesion molecule-1 (ICAM-1) on the surface of vascular endothelial cells, increase the content of tissue factor (TF) and von Willebrand factor in the extracellular matrix, and cause the upregulation of P38MAPK and AKT signaling pathways, thereby reducing inflammation and inhibiting thrombosis. So, how to buy such effective Irish Jazz Pharmaceuticals Defibrotide?

Domestic patients who need Irish Jazz Pharmaceuticals defibrotide can either go abroad to the United States, Ireland, Italy and other countries and regions to purchase it, or contact domestic professional and formal overseas medical service organizations (such as Medical Companion Travel) to obtain purchase channels for Irish Jazz Pharmaceuticals defibrotide. Through this method, patients can effectively avoid problems such as being unable to distinguish the authenticity of drugs, high round-trip costs, and complicated procedures. At the same time, patients can also more conveniently obtain the safe and good drugs they need.

Irish Jazz Pharmaceuticals, the company that owns Defibrotide, is a biopharmaceutical company that develops and commercializes products that address unmet medical needs. As one of the company's products, it is worth buying.

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