爱尔兰爵士制药去纤苷注射方法

(Defibrotide) is a mixture of single-stranded oligonucleotides with anti-thrombotic and fibrinolytic effects. In recent years, multiple clinical research results have shown that Defibrotide is a safe and effective drug for the prevention and treatment of hepatic veno-occlusive disease after HSCT. So, how to inject Defibrotide from Sir Irish Pharmaceuticals to be effective?

Defibrotide sodium (defibrinoside) can be administered via intravenous injection or oral administration. Intravenous administration can quickly reach the maximum blood concentration Cmax, and oral administration can reach Cmax 30 minutes later. 

The recommended dose of defibrotide for adult and pediatric patients is 6.25 mg/kg given every 6 hours as a 2-hour intravenous infusion. The dose should be based on the patient's baseline weight, which is defined as the patient's weight before the HSCT preparation protocol. Defibrotide was administered for a minimum of 21 days. If signs and symptoms of hepatic VOD have not resolved after 21 days, continue defibrotide until resolution of VOD or up to a maximum of 60 days. Defibrotide must be diluted prior to infusion.

Prior to administration of defibrotide, confirm that the patient is not experiencing clinically significant bleeding and is hemodynamically stable on no more than one vasopressor. Defibrotide was administered by constant intravenous infusion over a 2-hour period. Administer the diluted defibrotide solution using an infusion set equipped with a 0.2 μm in-line filter. Flush the intravenous administration line (peripheral or central) with 5% dextrose injection, USP, or 0.9% sodium chloride injection, USP, before and immediately after administration.

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