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(Defitelio) is a multi-component biochemical complex developed by Gentium SpA in Italy. It is produced from pig small intestinal mucosal genomic DNA through controlled depolymerization. The efficacy and safety of the drug have been confirmed by clinical trials. In order to ensure that patients can benefit from it, it is particularly important to master the correct use of the drug. So how to use defibrinated sodium?

Defibrinated sodium can be administered via intravenous injection or oral administration. Intravenous administration can quickly reach the maximum blood concentration Cmax. Cmax can be reached after 30 minutes of oral administration. In view of factors such as hydrolytic inactivation of digestive tract nucleases, DF small intestinal absorption efficiency and liver first-pass effect, the oral bioavailability is only 58-71%. The half-life of defibrinated sodium for injection is about 10-30 minutes, while the elimination of defibrinated sodium for oral administration takes several hours and is mainly excreted through urine and feces. The advantage of oral administration is that defibrotide sodium can exert its effect slowly and continuously.

Multiple biological activities are the most prominent feature of DF. In vitro and in vivo studies have shown that defibrinated sodium has anti-atherosclerotic, anti-inflammatory, anti-myocardial ischemia, fibrinolytic and anti-thrombotic activities. The anti-tumor application prospects of defibrinated sodium have recently attracted the attention of scholars. The detailed mechanism of action of defibrinated sodium has not yet been fully elucidated. On the one hand, it is related to the characteristics of the polyanion of defibrinated sodium. On the other hand, defibrinated sodium is a single-stranded deoxyoligonucleotide mixture. There are complementary pairings of bases in its molecule, which forms the basis of the sequence diversity and spatial conformation diversity of defibrinated sodium. These are directly related to the biological activity diversity of defibrinated sodium.

(Defibrinoside) has been confirmed to exert biological functions mainly by reacting with vascular endothelial cells. For example, the drug can increase the activity of fibrinolysis-related factors and inhibit the activity of coagulation-related factors. It has been confirmed in vitro that the drug is an agonist of plasmin and can increase the anticoagulant activity of heparin.

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