去纤维钠怎么购买？

(Defitelio) was approved for marketing by the EU EMA on October 18, 2013, and received orphan drug designation. On March 30, 2016, the drug was approved by the U.S. FDA for the treatment of adult and pediatric patients with hepatic venous occlusion and renal or lung abnormalities after blood or bone marrow hematopoietic stem cell transplantation, and was granted priority review status and orphan drug status.

Defibrotide (i.e., defibrotide sodium) was the first FDA-approved drug to treat severe hepatic venule occlusion. A phase III clinical trial study pointed out that patients with severe hepatic venule occlusion and organ failure received intravenous injection of defibrotide sodium 6.25 mg/kg every 6 hours after hematopoietic stem cell transplantation. The complete remission rate was significantly improved and the mortality rate was significantly reduced after 100 days. The most common adverse reactions include abnormally low blood pressure, diarrhea, vomiting, nausea and nosebleeds. After a series of measures, these adverse reactions can be effectively controlled.

So, if patients want to use defibrinated sodium for treatment, how should they purchase it?

Since defibrotide sodium has not yet been approved for marketing by the State Food and Drug Administration, patients cannot buy this drug in major domestic hospitals. However, patients can contact Medical Companion Travel to obtain defibrinated sodium sold overseas. It is understood that the price of defibrinated sodium with a specification of 200mg/bottle is around $21,600. Due to exchange rate fluctuations, drug prices will change, so you need to consult Medical Companions for specific prices.

After purchasing it, patients must follow the instructions or follow the doctor's advice: the recommended dosage of defibrotide sodium is 6.25 mg/kg, given every 6 hours as a 2-hour intravenous infusion. The minimum treatment time is 21 days. If the signs and symptoms of patients with hepatic veno-occlusive disease have not resolved after 21 days, treatment should be continued.

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