非布索坦要吃多久？

(febuxostat) is the latest xanthine oxidoreductase inhibitor in the world. It acts highly selectively on this oxidase to reduce the production of uric acid in the body and lower the concentration of uric acid, thereby effectively treating gout. The drug is currently on the market in many countries and regions, including China, and has brought new options and opportunities for the treatment of many gout patients.

So, for gout patients, how long should they take Febuxostat?

Since the progression of gout disease is different for each patient, there are also certain differences in physical constitution, and tolerance varies from person to person, so there is currently no clear conclusion as to how long febuxostat should be taken. However, based on past treatment experience, patients who insist on taking febuxostat for about 6 months can achieve the purpose of reducing uric acid concentration and achieve obvious therapeutic effects. However, there are some patients who can achieve good results without taking it for 6 months. Of course, some patients need to take it for a longer period of time to achieve the purpose of treating gout.

In order to achieve satisfactory therapeutic effects, patients must take the drug according to the instructions or doctor's advice when actually receiving Febuxostat (Febuxostat) treatment. The recommended starting dose of febuxostat is 40 mg/d, and the target is reached when the SUA drops below 360 μmol/L. After reaching the target during treatment, the dose is changed to 20 mg/d orally for continuous administration. For patients who have not reached the target after taking 40 mg/d for 1 week, the dose is increased to 80 mg/d.

Febuxostat is well absorbed after oral administration (bioavailability is 84%), and it is believed that the absorption of febuxostat from food or antacids is not clinically relevant. Therefore, patients do not need to consider food intake when actually taking it, and it can be taken alone or with food.

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