非布司他怎么吃效果好？

(Alias: Febuxostat) is an effective non-purine selective inhibitor of xanthine oxidase (XO). By selectively inhibiting xanthine oxidase, it can achieve the therapeutic effect of reducing serum uric acid. How to take Febuxostat to get the best effect?

How to take Febuxostat:

1. Febuxostat is recommended to be 40 mg or 80 mg once a day. The recommended starting dose of febuxostat is 40 mg once daily. For patients who have not achieved serum uric acid (sUA) less than 6 mg/dL 2 weeks after taking 40 mg, febuxostat 80 mg is recommended.

2. You can give it without food or using antacids.

3. No dose adjustment is required when taking febuxostat in patients with mild to moderate renal or hepatic impairment.

Precautions when using Febuxostat (alias: Febuxostat):

1. Gout flare-ups: An increase in flare-ups of gout is often observed during the initiation of antiuricemic drugs, including febuxostat. If a gout attack occurs during treatment, febuxostat does not need to be discontinued. Preventive treatment (i.e., initiating treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) or colchicine) may be beneficial until 6 months of age.

2. Cardiovascular events: In clinical trials, a higher incidence of cardiovascular embolic events was observed in patients treated with febuxostat than with allopurinol. Monitor for signs and symptoms of MI and stroke.

3. Elevated liver enzymes: Elevated transaminases have been observed in febuxostat-treated patients. Monitor liver function tests regularly.

(Alias: Febuxostat) is the latest XOR inhibitor developed in the world. It acts highly selectively on this oxidase to reduce the synthesis of uric acid in the body and reduce the concentration of uric acid, thereby effectively treating ventilation diseases.

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