非布司他的作用与功效

Function:

Febuxostat is an anti-gout drug used to treat chronic hyperuricemia with good effectiveness.

Gout occurs due to excessive production of uric acid in the body and reduced kidney clearance capacity, resulting in the accumulation of uric acid in the body, leading to the deposition of urate crystals in joints and various organs. Taking febuxostat can promote uric acid excretion and inhibit uric acid production, thereby effectively treating gout.

Febuxostat was first launched in the United States in March 2009 and is clinically used to treat hyperuricemia. Animal experiments show that compared with allopurinol, febuxostat is 10 to 30 times more powerful. The structure of febuxostat is a non-purine analogue, so it is selective in inhibiting xanthine oxidase and has little effect on other enzymes involved in purine and pyrimidine metabolism. Allopurinol is a purine analogue, which can affect the activity of other enzymes involved in purine and pyrimidine metabolism in the body, and is prone to some adverse reactions. The specificity of the inhibitory effect of febuxostat can avoid these possible adverse reactions.

Functions of febuxostat:

Research results show that long-term use of febuxostat can maintain long-term blood uric acid in most patients at ≤6.0 mg/dl. Mild to moderate impairment of renal function has no significant impact on the pharmacodynamics and pharmacokinetics of febuxostat. Therefore, the uric acid-lowering effect of febuxostat is no different from that of patients with normal renal function, and its safety is good.

Clinically, it should be considered for patients with mild to moderate renal impairment, allopurinol intolerance, and current treatments that cannot maintain blood uric acid at the target value. In addition, when febuxostat is used to treat hyperuricemia, it may easily lead to an acute attack of gout in the early stages. Therefore, it is recommended that patients taking febuxostat take colchicine or NSAIDs during the first 6 months of treatment to avoid acute attacks of gout.

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