非布司他在国内的售价多少呢？

It is a drug approved in 2009 for the treatment of chronic hyperuricemia. Compared with the traditional treatment drug allopurinol, febuxostat is more effective in reducing uric acid. The most common adverse reactions are abnormal liver function, diarrhea and rash. Medication guidelines recommend a starting dose of 40 mg/d. In patients with mild to moderate renal impairment (creatinine clearance [CrCl] 30-89 mL/min), the starting dose is the same as in patients with normal renal function. Today let’s find out how much febuxostat sells for in China? 

The price of original medicine in Japan is higher than that in India, about 1,500$ per box. Febuxostat produced by Zydus Pharmaceutical Factory in India has the same efficacy as the original drug, but the price is indeed much lower. The specification is 80mg*30 tablets/box. Its price is about 200$. Due to the floating exchange rate, the price cannot be accurate. For specific prices, please consult the regular overseas medical service company Medical Travel.

Usually, adult patients need to start taking this medicine from 10 mg, once a day, 10 mg once a day, and at the same time, the uric acid content in the body must be tested. After two weeks, the once-daily dosage can be increased to 20 mg, and after six weeks, the once-daily maintenance dosage can be increased to 40 mg, etc.

Appropriate increases or decreases can be made based on the doctor's judgment and needs. However, the maximum dosage once a day cannot exceed 60 mg. The ingredients in one tablet of this medicine are febuxostat 10 mg, 20 mg, and 40 mg. It must be taken according to the instructions. If you forget to take a dose, try to take the daily dose as quickly as possible when you realize this.

However, if the taking time is very close to the next taking time, please skip this taking time and take this medicine directly at the next taking time. It is strictly forbidden to take two days' worth of medication in one day.

Febuxostat and allopurinol are both xanthine oxidase inhibitors, but their molecular structures are completely different from allopurinol and purine. They can bind to xanthine oxidase through a non-competitive mechanism, inhibit xanthine enzyme activity, and inhibit the production of uric acid. Moreover, febuxostat not only inhibits the reduced form, but also inhibits the oxidized xanthine oxidase, so a small dose can exert a powerful inhibitory effect on xanthine oxidase.

The above is the price content, I hope it can help you!