非布索坦治疗期间需要注意什么？

Start with 10 mg/day for 2 weeks, then increase to 20 mg/day for 4 weeks, then increase to 40 mg/day. Starting with a low dose and gradually increasing the dose can prevent acute gout attacks caused by initial changes in blood uric acid levels. Treat with febuxostat 40 mg/day for 6 months, and review uric acid levels regularly. Generally, it takes 6 months to clean up excess blood uric acid in the body. Today we will learn about what should be paid attention to during treatment with febuxostat?

1. After starting treatment with febuxostat, an increase in gout attacks may be observed. This is caused by changing serum uric acid levels that reduce the activity of deposited urate. To prevent gout attacks while administering this product, concomitant administration of a nonsteroidal anti-inflammatory drug or colchicine is recommended.

2. In randomized controlled studies, patients taking this product [0.74per100P-Y (95%CI0.36-1.37)] were more likely to have cardiovascular thrombotic events (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke) than patients taking allopurinol [0.60per100P-Y (95%CI0.16-1.53)]. The relevant reasons are not yet clear. Monitor for signs and symptoms of myocardial infarction (MI) and stroke.

3. In randomized controlled studies, it was observed that transaminase levels were higher than 3 times the upper limit of normal (the patients taking this product and allopurinol increased respectively, AST: 2%, 2%, ALT: 3%, 2%). No dose-response relationship was found for the increase in transaminases. Liver function laboratory analysis recommends the use of this product for treatment in February and April, and periodic treatment thereafter. Please read the instructions carefully and use it as directed by your doctor. 

4. Patients should pay attention to monitoring the uric acid value when taking febuxostat. If the standard is reached, the dose can be adjusted appropriately. For secondary hyperuricemia, such as caused by organ transplantation, it is not suitable to use febuxostat to lower uric acid.

5. Some patients may experience liver function abnormalities after taking febuxostat, so liver function should be monitored regularly. If transaminases increase by more than three times the normal value, the drug should be discontinued. Some patients may also experience nausea, diarrhea, rash and other side effects, and some may also experience angioedema, acute renal failure, acute hemoglobin reduction, etc.

6. For people with cardiovascular and cerebrovascular diseases or those at risk of cardiovascular and cerebrovascular diseases, taking febuxin may increase the risk of thrombotic vascular diseases, so you should also pay attention to the prevention of related risks of cardiovascular and cerebrovascular diseases.

7. Febuxostat has played a corresponding role in the treatment of hyperuricemia in patients with gout. The specific taking time can be before or after meals. The dosage should be taken under the guidance of a professional doctor. There are not many related precautions for taking it. It is best for everyone to listen to the advice of a professional doctor and use it according to the instructions.

The above is the content of the precautions, I hope it can help you!