非布索坦的价格

The oral dosage is 40mg or 80mg, starting with a small dose of 40mg once a day. If the blood uric acid level is still 360umol/L after two weeks, it can be increased to 80mg, once a day. Febuxostat is a 2-arylthiazole derivative and a new, highly effective, non-purinic xanthine oxidase selective inhibitor. It reduces blood uric acid concentration by inhibiting the production of uric acid, and is suitable for the treatment of hyperuricemia in patients with gout. Today we will take a look at the price of generic febuxostat drugs.

The price of original medicine in Japan is higher than that in India, about 1,500$ per box. Febuxostat produced by Zydus Pharmaceutical Factory in India has the same efficacy as the original drug, but the price is indeed much lower. The specification is 80mg*30 tablets/box. Its price is about 200$. Due to the floating exchange rate, the price cannot be accurate. For specific prices, please consult the regular overseas medical service company Medical Travel.

A multicenter, double-blind, randomized phase II clinical study evaluated the safety and efficacy of febuxostat in gout. A total of 136 male and 17 female gout patients were randomly assigned to receive placebo or this product (40, 80 or 120 mg/d). After 4 weeks, tests found that the serum uric acid concentration of patients in each dose group of this product was significantly lower than before treatment. According to the dose, each group decreased by an average of 37%. %, 44% and 59%, while the patients in the placebo group only decreased by 2%; the vast majority of patients persisted in completing the trial. The incidence of adverse reactions in this product and the placebo group was similar, and most of these adverse reactions were mild and self-limiting, with common ones including diarrhea, pain, back pain, headache and joint pain.

Some patients with gout have elevated transaminases after taking febuxostat, but their liver enzymes return to normal after stopping the drug. Statistics show that among 306 gout patients treated with febuxostat, 38 cases developed liver function damage. The results of multivariate regression analysis showed that older age, habitual drinking, basic renal damage, use of statins and fatty liver are independent risk factors for liver function damage in gout patients using febuxostat. Gout patients with the above factors need to be more cautious when using febuxostat and monitor liver function regularly.

Febuxostat is the latest XOR inhibitor developed in the world. It acts on this oxidase highly selectively, reducing the synthesis of uric acid in the body and lowering the concentration of uric acid, thereby effectively treating ventilation diseases.

The above is the price content, I hope it can help you!